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U19. Clinical tests lab

U19. Clinical tests lab

U19-S02.

Animal Model Studies

This service is responsible for conducting regulatory studies for the pharmaceutical industry and interested companies. The safety and efficacy studies are carried out using small and large animal models for the different organic systems, also including animal models of different pathologies.

Customer benefits

These studies are carried out under strict quality regulations, certified with ISO-9001 and Good Laboratory Practices (GLP), quality standards that allow the production of high-precision results.
Therefore, safety and efficacy studies in animal models can be carried out in compliance with the strict guidelines of regulatory agencies, ensuring the reliability and traceability of all results and tests carried out in their different services.

Target customer

The services offered in this unit may be of interest to different companies and laboratories that work within the pharmaceutical industry. Companies whose objective is to test possible candidates for molecules, drugs or medical devices in animal models of specific pathologies.

References

  1. J Bote, et al. Novel ex-vivo database of a murine model of colorectal cancer using optical coherence tomography. Surg Endosc (2022) 36:S325–S674
  2. V Lucas-Cava, et al. Prostatic artery occlusion: Initial findings on pathophysiological response in a canine prostate model. Translational Andrology and Urology. Transl Androl Urol 2022.
  3. Soria F, et al. Heparin coating in biodegradable ureteral stents does not decrease bacterial colonization-assessment in ureteral stricture endourological treatment in animal model. Transl Androl Urol. 2021 Apr;10(4):1700-1710.
  4. Baez-Díaz C, et al. Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model. Sci Rep. 2020 Apr 28;10(1):7166.
  5. Moreno-Lobato, B, et al. Use of nanomedicine in preclinical wound healing studies. FarmaJournal; Salamanca T 4, N.º 1, (Feb 2019): 178.
  6. Picado Román, N, et al. Drugs most used in experimental animals in a Research Center. FarmaJournal; Salamanca T 4, N.º 1, (Feb 2019): 236.
  7. Moreno-Lobato B, et al. Analytical Validation Study of Hematological Parameters under Good Laboratory Practice Regulations in Different Laboratory Animal Species. Thromb Haemost Res. 2019; 3(1): 1018.
  8. Ballestín A, et al. A Pre-clinical Rat Model for the Study of Ischemia reperfusion Injury in Reconstructive Microsurgery. J Vis Exp. 2019 Nov 8;(153).
  9. R Blázquez , et al. Altered hematological, biochemical and immunological parameters in a porcine myocardial infarction model: predictive biomarkers for the severity of myocardial infarction. Veterinary Immunology and Immunopathology 205 (2018) 49–57.
  10. Vela FJ, et al. Evaluation of antigen-induced synovitis in a porcine model: Immunological, arthroscopic and kinetic studies. BMC Vet Res. 2017. Apr 7;13(1):93.

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U19-E02. Specific laboratory diagnostic equipment: Hematology, biochemistry, hormones, biomarkers analyzer

Specific laboratory diagnostic equipment: Hematology, biochemistry, hormones, biomarkers analyzer:

  • Automatic coagulometer (CLOT SP de RAL)
  • Biochemical Analysis (VetScan)
  • Solid state thermostatic equipment 37 º C + – 0,1 º C with magnetic stirrer system, 15 reaction cubiletes and a reacive bottle
  • Automatic coagulometer (AUTOCLOT SP de RAL)
  • Clinic auto-analyser (Metrolab 2300 de RAL)
  • Blood cells counter (MEK-6318. NIHON KOHDEN)
  • AQT90 FLEX analyzer (RADIOMETER)
  • Water purification system (Elix 3 de MILLIPORE)
  • Water purification system (Milli-Q Advantage A10 de MILLIPORE)
  • Laboratory freezer (MEDILOW-M SELECTA)
  • Vertical Freezer (SF-126) from -30 ºC to 150 L capacity
  • Digital automatic micropipettes
  • Centrifuge SELECTA (MIXTASEL 7000575)
  • Rotary shaker (NAHITA)
  • Recorder Device leukocyte (Leucoform 83 de CRISON)
  • Binocular microscope (LEICA CM E BA 220/20 W)
  • pH Meter (GLP 21 de CRISON)
  • NPT7 Gasometer analyzer (RADIOMETER)
  • i-STAT® 1 Analyzer (ABBOTT)
  • Veterinary Hematology Analyzer (MINDRAY BC-5300VET)
  • ABL80 FLEX Gasometer Analyzer (RADIOMETER)
  • Urine Analyzer (DIRUI H-100)
  • MAGLUMI, Chemiluminescence Analyzer (Snibe)
  • Ultrafreezer -80ºC (Froilabo)
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U19-E23. Ultrafreezer -80ºC (Froilabo)

Ultrafreezer -80ºC (Froilabo)

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U19-E22. MAGLUMI, Chemiluminescence Analyzer (Snibe)

MAGLUMI, Chemiluminescence Analyzer (Snibe)

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U19-E21. Urine Analyzer (DIRUI H-100)

Urine Analyzer (DIRUI H-100)

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U19-E20. ABL80 FLEX Gasometer Analyzer (RADIOMETER)

ABL80 FLEX Gasometer Analyzer (RADIOMETER)

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U19-E19. Veterinary Hematology Analyzer (MINDRAY BC-5300VET)

Veterinary Hematology Analyzer (MINDRAY BC-5300VET)

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U19-S03. Clinical Analysis Laboratory

Clinical Analysis Laboratory

The clinical analysis laboratory that performs a wide variety of analysis: (biochemistry, hematology, coagulation, urine analysis, blood gas analysis, different biomarkers, hormones, allergens) in various animal species (rat, mouse, rabbit, pig, sheep, dog, and cat). Specific methodologies are used in each animal species, having all techniques validated according to their physiological and pathological identity. It also has a formulation laboratory equipped to formulate, reconstitute and guarantee the correct storage of the test products used in these studies.

Customer benefits

The laboratories are certified with ISO-9001 and Good Laboratory Practices (GLP), strict quality standards that allow the production of high-precision results.
Also, the studies can be performed under regulatory requirements too, since the performing institution is Certified for Good Laboratory Practices.
Therefore, studies can be carried out in compliance with the strict guidelines of regulatory agencies, ensuring the reliability and traceability of all results and tests carried out in their different services.

Target customer

The services offered in this unit may be of interest to different companies and laboratories that work within the pharmaceutical industry. Companies whose objective is to test possible candidates for molecules, drugs or medical devices.
With this service, companies and laboratories ensure that they report reliable and reproducible results in all their studies, guaranteeing the traceability and viability of analyzes obtained.

References

  1. J Bote, et al. Novel ex-vivo database of a murine model of colorectal cancer using optical coherence tomography. Surg Endosc (2022) 36:S325–S674
  2. V Lucas-Cava, et al. Prostatic artery occlusion: Initial findings on pathophysiological response in a canine prostate model. Translational Andrology and Urology. Transl Androl Urol 2022.
  3. Soria F, et al. Heparin coating in biodegradable ureteral stents does not decrease bacterial colonization-assessment in ureteral stricture endourological treatment in animal model. Transl Androl Urol. 2021 Apr;10(4):1700-1710.
  4. Baez-Díaz C, et al. Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model. Sci Rep. 2020 Apr 28;10(1):7166.
  5. Moreno-Lobato, B, et al. Use of nanomedicine in preclinical wound healing studies. FarmaJournal; Salamanca T 4, N.º 1, (Feb 2019): 178.
  6. Picado Román, N, et al. Drugs most used in experimental animals in a Research Center. FarmaJournal; Salamanca T 4, N.º 1, (Feb 2019): 236.
  7. Moreno-Lobato B, et al. Analytical Validation Study of Hematological Parameters under Good Laboratory Practice Regulations in Different Laboratory Animal Species. Thromb Haemost Res. 2019; 3(1): 1018.
  8. Ballestín A, et al. A Pre-clinical Rat Model for the Study of Ischemia reperfusion Injury in Reconstructive Microsurgery. J Vis Exp. 2019 Nov 8;(153).
  9. R Blázquez , et al. Altered hematological, biochemical and immunological parameters in a porcine myocardial infarction model: predictive biomarkers for the severity of myocardial infarction. Veterinary Immunology and Immunopathology 205 (2018) 49–57.
  10. Vela FJ, et al. Evaluation of antigen-induced synovitis in a porcine model: Immunological, arthroscopic and kinetic studies. BMC Vet Res. 2017. Apr 7;13(1):93.
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U19-E14. Recorder Device leukocyte (Leucoform 83 de CRISON)

Recorder Device leukocyte (Leucoform 83 de CRISON)

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U19-E05. Blood cells counter (MEK-6318. NIHON KOHDEN)

Blood cells counter (MEK-6318. NIHON KOHDEN)

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