U3-S03. Special amino acids for peptidomimetics synthesis (Remote) OUTSTANDING

Special amino acids for peptidomimetics synthesis (Remote) OUTSTANDING

– Synthesis of N-alkyl amino acids and other special amino acids
– Synthesis of peptoids (N-alkylglycine oligomers).
– Synthesis of β-peptide, γ- peptides, β,γ-peptides and α,β-peptides
– Synthesis of peptidomimetics
– Synthesis of hybrid-heterocycle- peptides

Customer benefits

• Extensive experience in the synthesis of peptide oligomers from non-natural amino acids such as β-peptides, γ-peptides, β,γ-peptides and α,β-peptides.
• Experience with peptides and peptide mimetics in solid phase and in solution.
• Development of various strategies for large-scale production (hundreds of mg) of peptidomimetics.

Target customer

• Research groups (drug delivery, molecular biology, pharmacology, nanotechnology, biotechnology)
• Companies (biotech and pharma companies).

References

• Hybrid cyclobutane/proline-containing peptidomimetics: the conformational constraint influences their cell-penetration ability. Illa, Ona ; Ospina, Jimena; Sanchez-Aparicio, Jose-Emilio; Pulido, Ximena ; Abengozar, Maria Angeles; Gaztelumendi, Nerea; Carbajo, Daniel; Nogues, Carme; Rivas, Luis ; Marechal, Jean-Didier; Royo, Miriam ; Ortuño, Rosa M. International Journal of Molecular Sciences (2021), 22, 5092.
• Chiral cyclobutane-containing cell-penetrating peptides as selective vectors for anti-Leishmania drug delivery systems. Illa, Ona ; Olivares, Jose-Antonio; Gaztelumendi, Nerea; Martinez-Castro, Laura; Ospina, Jimena; Abengozar, Maria-Angeles; Sciortino, Giuseppe ; Marechal, Jean-Didier; Nogues, Carme; Royo, Miriam; Rivas, Luis; Ortuno, Rosa M. International Journal of Molecular Sciences (2020), 21, 7502.
• A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D1 and D2 dopamine receptors. Molero, Anabel; Vendrell, Marc; Bonaventura, Jordi; Zachmann, Julian; Lopez, Laura; Pardo, Leonardo; Lluis, Carme; Cortes, Antoni; Albericio, Fernando; Casado, Vicent; Royo, Miriam. European Journal of Medicinal Chemistry (2015), 97, 173-180.
• Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents. Cavalli, Silvia; Carbajo, Daniel; Acosta, Milena; Lope-Piedrafita, Silvia; Candiota, Ana Paula; Arus, Carles; Royo, Miriam; Albericio, Fernando. Chemical Communications (2012), 48, 5322-5324.