High Resolution Magic Angle Spinning (HR-MAS) NMR
The NMR service is equipped with a High resolution NMR Spectrometers: a 600 MHz, spectrometer dedicated NMR studies that are more demanding in terms of sensitivity. This system is also equipped with a high resolution magic angle spinning (HR-MAS) NMR to analyze heterogeneous samples (tissue biopsies or partially insoluble compounds).
Applications of NMR spectroscopy to chemistry range from structure elucidation of small molecules to studies of ligand-protein interactions.
Customer benefits
We have SOPs and ISO9001 certification. We also have specialist technicians for the use of the equipment.
This service is essential for metabolomic analysis of intact tissue (biopsies)
Target customer
Any company or research group interested in:
- Acquisition of 1 H and 31P HR-MAS NMR spectra.
- Preparation of tissue samples for HR-MAS NMR spectroscopy.
- Basic processing of NMR spectra.
References
Kawashima Y, Nagai H, Konno R, Ishikawa M, Nakajima D, Sato H, Nakamura R, Furuyashiki T, Ohara O. Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry. J Proteome Res. 2022 Jun 3;21(6):1418-1427. doi: 10.1021/acs.jproteome.2c00023. Epub 2022 May 6. PMID: 35522919; PMCID: PMC9171847.