U28-S01. Magnetic Resonance Imaging (MRI)

Magnetic Resonance Imaging (MRI)

Magnetic Resonance Imaging (MRI) is a very versatile technique that offers not only excellent morphological information, but also functional and physiological. Furthermore, important advances during last years in the development of highly sensitive contrast agents using nanotechnology approaches have brought MRI into the molecular imaging area. Thus, small animal MRI scanners have become a key tool in the development of magnetic nanoparticles for medical diagnosis and therapy.

Customer benefits

We have SOPs and ISO9001 certification. We also have specialist technicians for the use of the equipment.

This service is essential to:

• Anatomical Studies: tumors, inflammation, Degenerative diseases, etc.
• Functional Studies: brain perfusion, vascular permeability, in vivo metabolic profiling, etc.
• Pharmocokinetics and Biodistribution of new Contrast Agents (or any drug magnetically labeled)
• Monitoring of Drug Delivery and Targeting
• Follow up of Therapy Response

Target customer

Any company or research group interested in:

• Morphological imaging: T1-weighted, T2-weighted, PD, diffusion-weighted, etc.
• T1 and T2 Dynamic Imaging.
• Diffusion Imaging: ADC, DTI.
• Phantom-based relaxivity measurements.
• Cardiac Imaging.
• Single Voxel Spectroscopy.
• Image processing, analysis, and quantification.
• Close integration with other BIONAND units for associated animal handling and histology services.

References

1. Caro C, Guzzi C, Moral-Sánchez I, Urbano-Gámez JD, Beltrán AM, García-Martín ML. Smart Design of ZnFe and ZnFe@Fe Nanoparticles for MRI-Tracked Magnetic Hyperthermia Therapy: Challenging Classical Theories of Nanoparticles Growth and Nanomagnetism. Adv Healthc Mater. 2024 Feb 2:e2304044. doi: 10.1002/adhm.202304044. Epub ahead of print. PMID: 38303644.
2. Caro C, Avasthi A, Paez-Muñoz JM, Pernia Leal M, García-Martín ML. Passive targeting of high-grade gliomas via the EPR effect: a closed path for metallic nanoparticles? Biomater Sci. 2021 Nov 23;9(23):7984-7995. doi: 10.1039/d1bm01398j. PMID: 34710207.
3. Borrego LG, Recio R, Moreno N, Chelouan A, Álvarez E, Sánchez-Coronilla A, Caro C, Pearson JR, García-Martín ML, Khiar N, Fernández I. Enantioselective synthesis of 4-amino-3,4-dihydrocoumarins and their non-cyclic hydroxyester precursors: Biological evaluation for the treatment of glioblastoma multiforme. Eur J Med Chem. 2022 Dec 5;243:114730. doi: 10.1016/j.ejmech.2022.114730. Epub 2022 Sep 1. PMID: 36088758.
4. Gómez-González E, Núñez NO, Caro C, Garcia-Martín ML, Ocaña M. Carboxylate functionalized NaDy(MoO4)2 nanoparticles with tunable size and shape as high magnetic field MRI contrast agents. J Colloid Interface Sci. 2023 Jan;629(Pt A):310-321. doi: 10.1016/j.jcis.2022.08.130. Epub 2022 Aug 24. PMID: 36081210.