Dosing of test substances and non clinical specimen drawing in rodent and non-rodent species
We provide a specialised and precise infraestructure to conduct preclinical studies that are crucial on the development of drugs and biological products. We employ advanced dosification techniques to accurately administer test substances to the study species, ensuring the correct application of the doses needed to assess the safety and efficacy of compounds under development.
Our team is highly trained in the collection of samples as blood, tissues and biological fluids, ensuring that high quality samples are obtained for subsequent analysis. This is essential to evaluate pharmacokinetics, pharmacodynamics and toxicity of the compounds under study.
In addition, we cover a wide-range of species, from rodents like mouse and rats to non-rodents like sheeps, pigs and rabbits. This allows for a more comprehensive evaluation of safety and efficacy of the compounds under development in different animal models.
Customer benefits
This service provides with rigurous certifications like ISO-9001 and Good Laboratory Practices, ensuring high quality standards for the production of precise results. This enables the performance of preclinical. Safety and efficacy studies in animal models in full compliance with regulatory guidelines, ensuring the reliability and traceability of all data generated.
In addition, the team is certified by the Spanish Agency of Medicines and Sanitary Products for a variety of studies, including substances dosing, biocompatibility, toxicity, tolerance and pharmacodynamics studies.
Target customer
- Pharmaceutical and Biotechnological Research Labs.
- Universities and Academic Institutions.
- Medical devices Companies.
- Governmental Regulatory Agencies.
- Research Centres from Hospitals.
- Animal feed and Nutrition Companies.
- Toxicological and Safety Labs.
- Cosmetics and Selfcare Companies.
Additional information
Selected references:
- Blázquez R, Sánchez-Margallo FM, Álvarez V, Matilla E, Hernández N, Marinaro F, Gómez-Serrano M, Jorge I, Casado JG, Macías-García B. Murine embryos exposed to human endometrial MSCs-derived extracellular vesicles exhibit higher VEGF/PDGF AA release, increased blastomere count and hatching rates. PLoS One. 2018 Apr 23;13(4):e0196080.
- Marinaro F, Pericuesta E, Sánchez-Margallo FM, Casado JG, Álvarez V, Matilla E, Hernández N, Blázquez R, González-Fernández L, Gutiérrez-Adán A, Macías-García B. Extracellular vesicles derived from endometrial human mesenchymal stem cells improve IVF outcome in an aged murine model. Reprod Domest Anim. 2018 Sep;53 Suppl 2:46-49.