In vivo safety and efficacy studies of nanomaterials, biomaterials and new drugs in rodent and non-rodent species
We offer a service to evaluate therapeutical potential and safety of these innovative materials and compounds on a preclinical environment. In terms of safety assessment, we carry out exhaustive studies to evaluate potential side effects of nanomaterials, biomaterials and new drugs on the body. This includes monitoring of clinical signs, hematological and biochemical parameters,as well as the histopathological evaluation of organs and tissues.
Our service also allows to evaluate therapeutic efficacy of nanomaterials, biomaterials and new drugs in animal models relevant to the disease or condition under study.
This can include the measuring of specific biomarkers, the evaluation of inmune response and the monitoring of disease progress.
Customer benefits
The team is certified by the Spanish Agency of Medicines and Sanitaty Products for a wide variety of studies like “Dosage of problem substance and non clinical sampling“, “Biocompatibility studies of sanitary products“, “In vivo Toxicity“, “Tolerance“ and “Pharmacodinamycs“. In addition, we are certified with ISO-9001 and Good Laboratory Practices (BPL). This allows to carry out preclinical, safety and efficacy studies in animal models, complying with regulations and ensuring the reliability and traceability of the results and tests performed.
Target customer
Pharmaceutical industries: Need to evaluate safety and efficacy of new drugs in animal models prior the clinical trials.
Biotechnology: It requires preclinical studies to demonstrate safety and efficacy of nanomaterials or medical biomaterials.
Medical devices: Seek to evaluate biocompatibility and efficacy of their products containing nanomaterials or biomaterials.
Regulatory Agencies: Require in vivo study data to evaluate safety and efficacy of these materials and drugs prior to its clinical approval.
In addition to the above, also clinical, preclinical and academic researchers.
Additional information
Selected publications:
- Durán-Rey D, Brito-Pereira R, Ribeiro C, Ribeiro S, Sánchez-Margallo JA, Crisóstomo V, Irastorza I, Silván U, Lanceros-Méndez S, Sánchez-Margallo FM. Development and evaluation of different electroactive poly(vinylidene fluoride) architectures for endothelial cell culture. Front Bioeng Biotechnol. 2022 Oct 19;10:1044667.
- Gómez-Blanco JC, Galván-Chacón V, Patrocinio D, Matamoros M, Sánchez-Ortega ÁJ, Marcos AC, Duarte-León M, Marinaro F, Pagador JB, Sánchez-Margallo FM. Improving Cell Viability and Velocity in μ-Extrusion Bioprinting with a Novel Pre-Incubator Bioprinter and a Standard FDM 3D Printing Nozzle. Materials (Basel). 2021 Jun 5;14(11):3100.