In vivo PK/PD assays in rodent and non-rodent species
Our PK/PD in vivo assay services, offers a wide range of Specialised resources and capabilities to meet our clients needs in the field of pharmaceutical development and biomedical research. Among the services we can offer are the following:
Customised Study design and Execution: We are committed to working closely with our clients to design study protocols tailored to their specific needs. Whether it is to evaluate the pharmacokinetics of a new compound or to understand its pharmacodynamic effect, we ensure that every study is tailored to its unique research objectives.
Our service covers a variety of tests and measurements to evaluate absorption, distribution, metabolism and excretion of compounds as well as their biological and pharmacological effect. This includes analysis of blood samples, tissues and other biological fluids, as well as biomarker assessments and physiological responses.
We count with modern facilities and up to date equipment to carry out PK/PD in vivo assays accurately and efficiently. Our technology allows us to obtain high quality data that are essential for decision-making in drug development
Customer benefits
We count with ISO-9001 and Good Laboratory Practices accreditations, which guarantee the accuracy of our results. This allows us to carry out preclinical research and safety and efficacy studies in rodent and non-rodent animal models, complying with regulatory standards and ensuring the reliability of our tests. Besides that, our team is authorised with the Spanish Agency of Medicines and Sanitary Products (AEMPS) to carry out a variety of studies, including substance dosing and pharmacodynamics, which supports the verification of efficacy, safety and biocompatibility.
Target customer
Any entity involved In the development, research or regulation of pharmaceuticals and therapeutics, could benefit from an in vivo PK/PD assay service. Such as, pharmaceuticals, clinical researchers, medical device companies, agrochemical companies, etc.
Additional information
Selected references:
- de Pedro MÁ, Gómez-Serrano M, Marinaro F, López E, Pulido M, Preußer C, Pogge von Strandmann E, Sánchez-Margallo FM, Álvarez V, Casado JG. IFN-Gamma and TNF-Alpha as a Priming Strategy to Enhance the Immunomodulatory Capacity of Secretomes from Menstrual Blood-Derived Stromal Cells. Int J Mol Sci. 2021 Nov 10;22(22):12177.
- Soria F, Morcillo E, Serrano A, Budia A, Fernández I, Fernández-Aparicio T, Sanchez-Margallo FM. Evaluation of a New Design of Antireflux-biodegradable Ureteral Stent in Animal Model. Urology. 2018 May;115:59-64.
- Blázquez R, Sánchez-Margallo FM, Crisóstomo V, Báez C, Maestre J, García-Lindo M, Usón A, Álvarez V, Casado JG. Intrapericardial administration of mesenchymal stem cells in a large animal model: a bio-distribution analysis. PLoS One. 2015 Mar 27;10(3): 0122377.