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Posts Taged 3d-bioprinting

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3D Printing and Bioprinting for Pharmaceutical and Medical Applications

Researchers of CIBER-BBN group NanoBioCell – NANBIOSIS U10 Drug Formulation unit Jose Luis Pedraz Muñoz, Laura Saenz del Burgo Martínez, Gustavo Puras Ochoa, Jon Zarate Sesma have edited the book “3D Printing and Bioprinting for Pharmaceutical and Medical Applications”

The increasing availability and decreasing costs of 3D printing and bioprinting technologies are expanding opportunities to meet medical needs. 3D Printing and Bioprinting for Pharmaceutical and Medical Applications discusses emerging approaches related to these game-changer technologies in such areas as drug development, medical devices, and bioreactors.

Key Features:

  • Offers an overview of applications, the market, and regulatory analysis
  • Analyzes market research of 3D printing and bioprinting technologies
  • Reviews 3D printing of novel pharmaceutical dosage forms for personalized therapies and for medical devices, as well as the benefits of 3D printing for training purposes
  • Covers 3D bioprinting technology, including the design of polymers and decellularized matrices for bio-inks development, elaboration of 3D models for drug evaluation, and 3D bioprinting for musculoskeletal, cardiovascular, central nervous system, ocular, and skin applications
  • Provides risk-benefit analysis of each application
  • Highlights bioreactors, regulatory aspects, frontiers, and challenges

This book serves as an ideal reference for students, researchers, and professionals in materials science, bioengineering, the medical industry, and healthcare.

For table of contents and further deatails:

3D Printing and Bioprinting for Pharmaceutical and Medical Applications. ISBN 9781032228662332 Pages 73 B/W Illustrations. Published September 27, 2023 by CRC Press

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The role of microfluidics and 3D-bioprinting in the future of exosome therapy. A high impact review

Researchers of the NanoBioCel research group of the University of the Basque Country (UPV/EHU) and CIBER BBN, belonging to NANBIOSIS U10 Drug Formulation, Bioaraba, and CONICET Foundation of Argentina, have collaborated in a studio entitled: “The role of microfluidics and 3D-bioprinting in the future of the exosome therapy” which has been published in the journal Trends in Biotechnology, whose editorial seeks particularly relevant articles.

The importance of this publication lies in the novelty and potential of nanovesicles as new therapeutic agents and the versatility of microfluidic technology in combination with 3D bioprinting to bring nanovesicles closer to the clinic.

Article of reference:

Mikele Amondarain, Idoia Gallego, Gustavo Puras, Laura Saenz-del-Burgo, Carlos Luzzani, José Luis Pedraz, “The role of microfluidics and 3D-bioprinting in the future of exosome therapy”, Trends in Biotechnology,
2023, ISSN 0167-7799
https://doi.org/10.1016/j.tibtech.2023.05.006.

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III Course on Introduction to research and laboratory techniques in Biosciences

CCMIJU has organised the III Course on Introduction to research and laboratory techniques in Biosciences, which wil take place at JUMISC on December, 18th, 2020 under the Direction of Esther López Nieto and Javier García Casado, Scientific Director of NANBIOSIS U14 Cell Therapy. Other researchers of NANBIOSIS Units offer their expertise as Beatriz Moreno Lobato, Scientific Diector NANBIOSIS U19 and Luis Dávila Gómez, Scientific Director of NANBIOSIS U22

The course contents are distributed in the following blocks:

Block I. Knowledge pills for research – Theory
Research career and aid for hiring (Dr JG Casado). 30 min
Communication of research results (Dra. E López). 30 min
Introduction to bibliographic resources. (Dra. R Blázquez). 30 min
Research Projects: preparation and evaluation (Dr JG Casado). 30 min
Protection of research results. Intellectual and industrial property. (JL Añover). 30 min

Block II. Knowledge pills for research – exercises / case studies
Practical case 1: Bibliographic search and Commentary and assessment of different scientific communications: 1.5h
Block III. RNA and DNA: gene expression and genetic studies in reproduction
Introduction to the analysis of gene expression using qPCR (F Marinaro and E López). 1h 30min
Pre-implantation genetic diagnosis in assisted reproduction clinics (E Delgado). 1 hour

Block IV. Proteins and proteome: protein expression studies and massive proteomics analysis / identification
Protein expression study I: Introduction to immunoprecipitation and western blotting techniques (E López). 1 hour
Introduction to the study of proteins II: Generalities and principles of proteomics in cardiovascular research (I Jorge). 1h 30min

Block V. Cell cultures: stem cell cultures and production for clinical uses
Cell cultures I: Isolation of adult stem cells and characterization (R Blázquez). 1 hour
Cell cultures II: Production, commercialization and clinical uses of cell therapy (O delaRosa). 1h 30min

Block VI. Miscelanea: Histology, clinical analysis, 3D bioprinting and animal experimentation
Basic fixation, inclusion and staining techniques for histology (A Usón). 1 hour
Basic techniques for determining blood parameters: Biochemistry and hematology (B Moreno). 1 hour
Technology and materials in the 3D bioprinting laboratory (JC Gómez). 1 hour
Minimally invasive experimental procedures in laboratory animals (L Dávila). 1 hour

Block VII: Laboratory techniques in biosciences – exercises / practical cases
Practical case-example 2: Analysis of qPCR results. 1,5h

Further information: Programm and inscriptions

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New 3D culture device to better understand how tumours work

Scientist of NANBIOSIS in collaboration with other CIBER-BBN researchers have developed a sophisticated microfluidic biomedicine device capable of reproducing in vitro and by 3D bioprinting the complexity of different tumour types. This device allows tumour cells to grow in a 3D environment where nutrients and oxygen are supplied in a controlled way through small capillaries, thus mimicking the body’s own blood vessels.

Thanks to this new technology, it is now possible to reproduce in a controlled way all the processes of the tumour environment, which could help to develop new treatments and combinations of drugs that are more effective for the treatment of these tumours.

In this study, published in Scientific Reports, have participated researchers from the Group of Applied Mechanics and Bioengineering (AMB) of the University of Zaragoza , which coordinates Unit 13 of NANBIOSIS .

Article of reference:

Development and characterization of a microfluidic model of the tumour microenvironment.Jose M. Ayuso, María Virumbrales-Muñoz, Alodia Lacueva, Pilar M. Lanuza, Elisa Checa-Chavarria, Pablo Botella, Eduardo Fernández, Manuel Doblare, Simon J. Allison, Roger M. Phillips, Julián Pardo, Luis J. Fernandez e Ignacio Ochoa. Scientific Reports. 10.1038/srep36086

New 3D culture device to better understand how tumours work
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