Services

Platform 1 Biomolecules production

• U1-S01. Molecular Cloning (Biomolecules production)
• U1-S02. Bioproduction of proteins
• U1-S03. Proteins purification
• U1-S04. Consultancy in protein production
• U1-S05. Training courses in protein production (Biomolecules production)
• U1-S06. Criopreservation
• U2-S01. Scientific and technical support
• U2-S02. Hapten design and synthesis
• U2-S03. Preparation of Bioconjugates and Molecular Probes
• U2-S04. Polyclonal Antibody Production
• U2-S05. Monoclonal Antibody development
• U2-S06. In vitro antibody production
• U2-S07. Antibody purification
• U2-S08. Inmunochemical methods development
• U28-S07. Transmission Electron Microscopy (TEM)
• U29-S01. Synthesis of oligonucleotides and characterization (On-site & Remote). OUTSTANDING
• U29-S02. Modification of oligonucleotides. (Remote) OUTSTANDING
• U29-S03. Special nucleotides for oligonucleotide synthesis. (Remote) OUTSTANDING
• U3-S01. Synthesis of peptides and characterisation (On-site&Remote) OUTSTANDING
• U3-S02. Post synthesis peptide modification (On-site&Remote) OUTSTANDING
• U3-S03. Special amino acids for peptidomimetics synthesis (Remote) OUTSTANDING
• U3-S04. Peptide libraries (Remote) OUTSTANDING

Platform 2 Biomaterials & nanomaterials production

• U6-S01. Use of High-pressure laboratory-scale plant
• U6-S02. High-pressure phase analysis – solubility, emulsification (Remote) OUTSTANDING
• U6-S03. Design of experiments (DOE SOFTWARE)
• U6-S04. Analysis of particle size, concentration and Z-potential of nanoparticles (On-site&Remote) OUTSTANDING
• U6-S05. Freeze dryer
• U6-S06. Pulse-free microfluidic system
• U6-S07. Interactions of two biomolecules with respect to binding kinetics and affinity by surface plasmon resonance (SPR).
• U6-S08. Tangential flow filtration
• U6-S09. Multimode plate reader
• U6-S11. Specific density of powders (On-site&Remote) OUTSTANDING
• U6-S12. Packed (tapped) density (On-site) OUTSTANDING
• U6-S14. Quantitative studies of biomolecular interactions by calorimetric measurements (On-site) OUTSTANDING
• U7-S01. Training Courses in the Use of microfabrication equipment
• U7-S03. Characterization by SEM
• U7-S04. Lytography by e-beam
• U7-S07. Photolithography and soft-lithography manufacturing processes
• U7-S08. Fabrication of Chromium masks
• U7-S09. Thin layer deposition
• U7-S10. Advising and consulting in micro and nanofabrication
• U7-S11. Contact angle
• U8-S01. Design, fabrication and encapsulation of microelectrodes (based on gold or platinum) on different rigid (Si, SiC or Pyrex) or flexible polymeric substrates
• U8-S02. Electrochemical and electrical characterization of the above mentioned microelectrodes (On-site&Remote) OUTSTANDING
• U8-S04. Graphene growth services (On-site&Remote) OUTSTANDING
• U8-S05. Deposition of thin films (Polyimide, Parylene) for the fabrication of flexible devices or encapsulation purposes (On-site&Remote) OUTSTANDING.
• U8-S06. Encapsulation or fabrication of 3D strcutures via 3D printing.
• U9-S01. Synthesis of nanoparticles by laser induced-pyrolysis
• U9-S02. Synthesis of nanoparticles by wet methods and microfluidic technology
• U9-S03. Characterization of nanoparticles
• U9-S04. Microfluidics and microwave-assisted production of nanoparticles
• U9-S05. Generation and control of nanoparticle aerosols
• U9-S06. Consultancy

• U10-S01. Design & Development of pharmaceutical forms
• U10-S02. Design & Development of micro- & nanocapsules
• U10-S03. Design & Development of lipid nanoparticles
• U10-S04. Design & Development of living cells containing microparticules
• U10-S08. 3D bio-impression of scaffolding for regenerative medicine (On-site&Remote) OUTSTANDING
• U10-S09. Characterization and development of pulmonar formulations (On-site&Remote) OUTSTANDING

Platform 3 Preclinical validation Tissue, Biomaterials and Surfaces Characterization

• U12-S01. Characterization of colloidal dispersions by Dynamic and Static Light Scattering (DLS and SLS) and Light Diffraction
• U12-S02. Measuring NP aggregation properties and surface area
• U12-S03. Determination of the phase behavior of surfactant and polymers systems
• U12-S04. Rheology, viscometry and densimetry
• U12-S05. Surface and interfacial tensiometry
• U12-S06. Surface hydrophobicity characterization
• U12-S07. Evaluation of colloidal stability
• U12-S08. Characterization of materials by high resolution optical microscopy with spectral analysis and scanning electron microscopy
• U13-S01. MicroCT
• U13-S03. Fatigue tests Instron 8874
• U13-S04. Dynamic mechanical analysis Instron 8874
• U13-S05. Uniaxial test Instron MicroTester
• U13-S06. Confined compression tests Instron MicroTester
• U13-S08. Atomic Force Microscopy indentation test
• U13-S09. Compression-shear test cellscale MicroTester G2
• U14-S01. Cell cultures
• U14-S02. Flow Cytometry
• U14-S04. Cytokine quantification assays
• U14-S05. Determination of cytokine concentration by flow cytometry
• U14-S06. Lymphocyte proliferation assay
• U15-S01. Magnetometry (Remote) OUTSTANDING
• U15-S02. Relaxometry (Remote) OUTSTANDING
• U16-S01. X-ray photoelectron spectroscopy service
• U16-S04. Detection of secondary ions by time-of-flight mass spectrometry service (TOF-SIMS)
• U16-S05. Contact angle goniometry characterisation service
• U16-S06. Topographical characterisation service using optical profilometry
• U16-S07. Evaluation of the adhesion capacities and formation of biolayers of microorganisms on materials. Evaluation of bactericidal and/or bacteriostatic responses of materials. OUTSTANDING
• U16-S08. Electrical characterisation of surfaces through the determination of zeta potential
• U16-S09. Kelvin Probe Force Microscopy (KPFM) and Atomic Force Microscopy (AFM)
• U17-S01. Confocal Microscopy Service
• U18-S01. In vivo nanotoxicology
• U18-S02. In vitro nanotoxicology
• U18-S03. In vivo antitumor activity
• U18-S04. In vitro Antitumor Activity
• U18-S05. Histological analyses
• U19-S01. Preclinical studies
• U19-S03. Clinical Analysis Laboratory
• U30-S01. Sample preparation for proteomic analysis
• U30-S02. Determination of molecular mass of peptides, proteins and other biomolecules
• U30-S03. Protein identification by mass spectrometry (MS) or MS/MS
• U30-S04. Quantitative shotgun proteomics by nLC-MS/MS
• U30-S05. Targeted proteomics analysis by MRM or PRM-MS
• U30-S06. Protein or peptide separation by liquid chromatography
• U30-S07. Protein separation by one- or two-dimensional gel electrophoresis
• U30-S08. Luminex or ELISA assay development and analysis
• U30-S09. Data analysis of proteomics experiments

Platform 4 Preclinical validation bioimaging

• U20-S01. Non-invasive optical imaging (bioluminescence and fluorescence) (Remote) OUTSTANDING
• U20-S013. Detection of microbial (bacterial and mycoplasma) contaminationpre
• U20-S014. Hemocompatibility: hemolysis, platelet aggregation, plasma coagulation times and complement activation
• U20-S015. Cytotoxicity: proliferation, LDH, apoptosis and ROS
• U20-S02. Animal models in oncology (Remote) OUTSTANDING
• U20-S03. In vivo Experimental consultancy (Remote) OUTSTANDING
• U20-S04. In vivo Efficay Assays of drugs, nanomedicines, biomaterials and others (Remote) OUTSTANDING
• U20-S05. In vivo Toxicology (Onsite&Remote) OUTSTANDING
• U20-S06. In vivo ADME and biodistribution assays (Remote) OUTSTANDING
• U20-S07. In vivo PK/PD assays (Remote) OUTSTANDING
• U20-S08. Immunotoxicity assays (On-site&Remote) OUTSTANDING
• U20-S09. X-ray imaging in vitro and in vivo (Remote) OUTSTANDING
• U20-S11. Histological porcessing, section and staining (Remote) OUTSTANDING
• U21-S01. In vivo Efficacy Assays of drugs, nanomedicines, biomaterials and others
• U22-S01. Animal Housing
• U22-S02. In vivo experimental design/consultancy for preclinal studies
• U22-S03. In vivo toxicology in rodent and non-rodent species
• U22-S04. In vivo biocompatibility studies of medical devices in rodent and non-rodent species
• U22-S05. In vivo PK/PD assays in rodent and non-rodent species
• U22-S06. In vivo safety and efficacy studies of nanomaterials, biomaterials and new drugs in rodent and non-rodent species
• U22-S07. Development of animal models of disease in large animals
• U22-S08. Dosing of test substances and non clinical specimen drawing in rodent and non-rodent species
• U23-S01. In vitro fertilisation studies and embryo culture media viability
• U23-S02. Embryo culture media viability studies
• U23-S03. Micromanipulation and microinjection
• U23-S04. Sperm, oocyte and embryo cryopreservation
• U23-S05. In vitro maturation
• U23-S06. IMSI System
• U23-S07. Laser System and Biopsed of blastomeres
• U23-S08. Oosight system
• U23-S09. Quality control for Human Assisted Reproduction clinics
• U24-S01 Evaluation of therapies for cardiovascular disease
• U24-S02. Medical Imaging for Minimally Invasive Surgery (Onsite&Remote) OUTSTANDING
• U25-S03. NMR spectrometer 400 MHz with HRMAS/CPMAS probes (Onsite&Remote) OUTSTANDING
• U25-S05. Preclinical horizontal spectrometer Biospec 7T (Onsite&Remote) OUTSTANDING
• U25-S06. Dynamic nuclear polarizer HyperSense® (Onsite&Remote) OUTSTANDING
• U25-S07. Focused Microwave Fixation System (Onsite&Remote) OUTSTANDING
• U25-S08. NMR consultancy for processing and interpreting data (Onsite&Remote)
• U25-S09. Access to specific software and database (Remote) OUTSTANDING
• U26-S01. NMR Structural Elucidation 11.7T
• U26-S02. NMR experiments in solid state & micro MRI 9.4T
• U26-S03. NMR-HRMAS Metabolomic Studies 14T
• U26-S04. In vivo Biomedical & metabolic imaging MRI 7T
• U26-S05. In vivo Biomedical & vertical functional imaging MRI-PET 3T
• U26-S06. Training Advice and assistance
• U28-S01. Magnetic Resonance Imaging (MRI)
• U28-S010. Scanning Electron Microscopy (SEM)
• U28-S011. Environmental SEM (ESEM)
• U28-S012. Cryo-ultramicrotomy (Onsite&Remote) OUTSTANDING
• U28-S013. High-pressure freezing
• U28-S014. Freeze substitution
• U28-S015. Sample vitrification
• U28-S016. Confocal Microscopy
• U28-S017. Multiphoton Microscopy
• U28-S018. Super-resolution microscopy
• U28-S019. Fluorescence microscopy
• U28-S02. Fluorescent and Bioluminescent Optical Imaging
• U28-S020. High Content Screening
• U28-S021. Nuclear Molecular Imaging (PET/SPECT/CT)(Onsite&Remote)
• U28-S03. Computed Tomography (CT)
• U28-S04. High Resolution Liquid NMR
• U28-S05. High Resolution Magic Angle Spinning (HR-MAS) NMR
• U28-S06. Time Domain NMR (TD-NMR)
• U28-S08. Cryo-TEM

Platform 5 High perfomance computing

• U27-S01. Remote access to HPC
• U27-S02. Software installation on demand
• U27-S03. Biomedical signals processing
• U27-S04. Modeling of the functional behaviour of tissues and organs
• U27-S05. Massive Parallel Processing
• U27-S06. Mass storage