U22-E09. Metabolic cages to perform toxicity studies in rodents
Metabolic cages to perform toxicity studies in rodents
+34 620 10 75 37info@nanbiosis.com
Metabolic cages to perform toxicity studies in rodents
We provide a specialised and precise infraestructure to conduct preclinical studies that are crucial on the development of drugs and biological products. We employ advanced dosification techniques to accurately administer test substances to the study species, ensuring the correct application of the doses needed to assess the safety and efficacy of compounds under development.
Our team is highly trained in the collection of samples as blood, tissues and biological fluids, ensuring that high quality samples are obtained for subsequent analysis. This is essential to evaluate pharmacokinetics, pharmacodynamics and toxicity of the compounds under study.
In addition, we cover a wide-range of species, from rodents like mouse and rats to non-rodents like sheeps, pigs and rabbits. This allows for a more comprehensive evaluation of safety and efficacy of the compounds under development in different animal models.
Customer benefits
This service provides with rigurous certifications like ISO-9001 and Good Laboratory Practices, ensuring high quality standards for the production of precise results. This enables the performance of preclinical. Safety and efficacy studies in animal models in full compliance with regulatory guidelines, ensuring the reliability and traceability of all data generated.
In addition, the team is certified by the Spanish Agency of Medicines and Sanitary Products for a variety of studies, including substances dosing, biocompatibility, toxicity, tolerance and pharmacodynamics studies.
Target customer
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Our experimental centre offers a service for the development of animal models of disease in large animals, providing a specialized platform for the advance of biomedical research. We are dedicated on creating preclinical models that accurately mimic human diseases in animals like pigs and sheeps, with the goal of facilitating the study of complex diseases and the assessment of new therapies.
We work with researchers to design and develop animal models, tailored to their specific needs. From the selection of the right animal to the methodology of disease induction, we ensure to create relevant and reliable models.
Customer benefits
Our institution is certified by the Spanish Agency of Medicines and Sanitary Products for a wide variety variety of studies like “Dosage of problem substance and non clinical sampling“, “Biocompatibility studies of sanitary products“, “In vivo Toxicity“, “Tolerance“ and “Pharmacodinamycs“. In addition, we are certified with ISO-9001 and Good Laboratory Practices (BPL).
Target customer
The development of animal models of disease in large animals of our institution serves a wide variety of clients, including academic researchers, pharmaceutical and biotechnological companies, medical devices companies, other research centres, regulatory agencies, etc. These clients need relevant and reliable animal models to conduct research and preclinical evaluation.
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We offer a service to evaluate therapeutical potential and safety of these innovative materials and compounds on a preclinical environment. In terms of safety assessment, we carry out exhaustive studies to evaluate potential side effects of nanomaterials, biomaterials and new drugs on the body. This includes monitoring of clinical signs, hematological and biochemical parameters,as well as the histopathological evaluation of organs and tissues.
Our service also allows to evaluate therapeutic efficacy of nanomaterials, biomaterials and new drugs in animal models relevant to the disease or condition under study.
This can include the measuring of specific biomarkers, the evaluation of inmune response and the monitoring of disease progress.
Customer benefits
The team is certified by the Spanish Agency of Medicines and Sanitaty Products for a wide variety of studies like “Dosage of problem substance and non clinical sampling“, “Biocompatibility studies of sanitary products“, “In vivo Toxicity“, “Tolerance“ and “Pharmacodinamycs“. In addition, we are certified with ISO-9001 and Good Laboratory Practices (BPL). This allows to carry out preclinical, safety and efficacy studies in animal models, complying with regulations and ensuring the reliability and traceability of the results and tests performed.
Target customer
Pharmaceutical industries: Need to evaluate safety and efficacy of new drugs in animal models prior the clinical trials.
Biotechnology: It requires preclinical studies to demonstrate safety and efficacy of nanomaterials or medical biomaterials.
Medical devices: Seek to evaluate biocompatibility and efficacy of their products containing nanomaterials or biomaterials.
Regulatory Agencies: Require in vivo study data to evaluate safety and efficacy of these materials and drugs prior to its clinical approval.
In addition to the above, also clinical, preclinical and academic researchers.
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Our PK/PD in vivo assay services, offers a wide range of Specialised resources and capabilities to meet our clients needs in the field of pharmaceutical development and biomedical research. Among the services we can offer are the following:
Customised Study design and Execution: We are committed to working closely with our clients to design study protocols tailored to their specific needs. Whether it is to evaluate the pharmacokinetics of a new compound or to understand its pharmacodynamic effect, we ensure that every study is tailored to its unique research objectives.
Our service covers a variety of tests and measurements to evaluate absorption, distribution, metabolism and excretion of compounds as well as their biological and pharmacological effect. This includes analysis of blood samples, tissues and other biological fluids, as well as biomarker assessments and physiological responses.
We count with modern facilities and up to date equipment to carry out PK/PD in vivo assays accurately and efficiently. Our technology allows us to obtain high quality data that are essential for decision-making in drug development
Customer benefits
We count with ISO-9001 and Good Laboratory Practices accreditations, which guarantee the accuracy of our results. This allows us to carry out preclinical research and safety and efficacy studies in rodent and non-rodent animal models, complying with regulatory standards and ensuring the reliability of our tests. Besides that, our team is authorised with the Spanish Agency of Medicines and Sanitary Products (AEMPS) to carry out a variety of studies, including substance dosing and pharmacodynamics, which supports the verification of efficacy, safety and biocompatibility.
Target customer
Any entity involved In the development, research or regulation of pharmaceuticals and therapeutics, could benefit from an in vivo PK/PD assay service. Such as, pharmaceuticals, clinical researchers, medical device companies, agrochemical companies, etc.
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We offer a service of in vivo biocompatibility studies of Medical devices, focused on evaluating safety and tolerability in rodent and non-rodent species. We can provide with tests that comply with rigorous regulatory standards, adapting to the needs of each device. Examples of tests include evaluation of skin irritation, subcutaneous implantation, localized toxicity studies, etc. We guarantee data integrity, working closely with researchers and manufacturers to continuously improve device performance.
Customer benefits
All facilities in our unit are certified according to ISO-9001 and Good Laboratory Practices (GLP), ensuring the accuracy of the results. This allows us to perform preclinical research and safety and efficacy studies in animal models according to regulatory criteria, guaranteeing the reliability of the tests performed. In addition, our team is authorized by the Spanish Agency of Medicines and Health Products (AEMPS) to carry out a variety of studies, from substance dosing to pharmacodynamics.
Target customer
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We offer a specialized service of in vivo Toxicology in both Rodent and Non-Rodent species to evaluate possible toxicological effects of chemical, pharmaceutical and biological compounds. Our veterinarians guarantee and ethical and safe environment, performing a wide variety of standard and customized tests, such as acute, subchronic, chronic, reproductive, developmental, toxicity and mutagenicity studies. We work according to rigorous ethical and regulatory standards to generate reliable data essential for risk assessment in product development.We work with researchers to design and develop animal models, tailored to their specific needs. From the selection of the right animal to the methodology of disease induction, we ensure to create relevant and reliable models.
Customer benefits
All areas and facilities integrated in the unit have obtained certifications according to ISO-9001 and Good Laboratory Practices (GLP) standards, guaranteeing the production of highly accurate results.
This allows us to carry out preclinical research and safety and efficacy studies in animal models in full compliance with the rigorous criteria established by regulatory agencies, ensuring the reliability and traceability of all results and tests performed in the different services that we offer.
Target customer
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Committed to excellence in preclinical research, we offer complete services on in vivo experimental design. We strive to facilitate the advancement of your research on an ethically and efficient way, wether in person or remotely. We work closely with researchers to maximise the quality of the data and minimize resource usage, always prioritizing animal welfare. Our facilities feature state of the art animal housing designed to ensure the comfort and safety of animals used in preclinical studies. Our services include guidance in animal model selection, personalized experimental design, ethical and regulatory supervision of in vivo procedures, and detailed data analysis to support result interpretation.
Customer benefits
Quality Certificate from AENOR (ER-0430/2002) according to UNE-EN-ISO 9001:2015.
Certificate of Compliance with Good Laboratory Practices (BPLI 23.05/001 AEMPS) to conduct studies in both human and veterinary medicine, including:
We also have an associated Animal Care and Use Committee (Authorized body by the Government of Extremadura)
Target customer
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One hall for the reception and handling of animals.
2 quarantinerooms pre-experimental process