Atomic Force Microscopy can be used to measure the forces between the probe and the sample as a function of their mutual separation. This can be applied to perform force spectroscopy.
Customer benefits
Low forces on cells (nano-scale).
Target customer
Public and private research groups focused on mechanobiology
Additional information
Encapsulation of therapeutic actives of interest in formulations for pulmonary administration with possibility of lyophilisation to obtain a powder. The service has two cutting-edge equipments for the characterization of pulmonary formulations:
SprayTec laser diffraction system: allows the measurement of spray particle and spray droplet size distributions in real-time for more efficient product development of sprays and aerosols, with robust and reproducible droplet size data.
Next Generation Impactor: has been designed specifically for the pharmaceutical industry for testing metered-dose inhalers, drypowder inhalers, nebulizers and nasal sprays. It consists of a high performance cascade impactor for classifying aerosol particles into micrometer size fractions, providing relevant information about their distribution in the respiratory tract.
Customer benefits
The formulations can be characterized, following SOPs, in terms of particle size, polydisperstity index and zeta potential. Importantly, this service can also offer real-time droplet size distribution and aerosol particles classification analysis by means of SprayTec and Next Generation Impactor (NGI) technology.
Target customer
References
Moreno-Sastre M, Pastor M, Esquisabel A, Sans E, Viñas M, Fleischer A, Palomino E, Bachiller D, Pedraz JL. Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis. Int J Pharm. 2016 Feb 10;498(1-2):263-73. doi: 10.1016/j.ijpharm.2015.12.028.
Additional information
The principle of 3D bioprinting consists of selecting the most suitable biomaterials and cell types to prepare a Bioink that should be able to promote cell growth and differentiation and present appropriate mechanical properties of the target tissue.
This service possess a wide variety of 3D bioprinting techniques avaliable, such as extrusion, droplet, electrospining, electrowritting and stereolithography.
Customer benefits
One of the main characteristics of this additive manufacturing technique is its ability to bioprint the desired layers, with specific cell orientation , and desired morphology of the bioprinted 3D scaffold in order to ressemble, as much as possible, the tissue of interest. To achieve this goal, rheology, texturometry, printability and biological assays are carried out.
On the one hand, this technology can be employed to develop 3D scaffolds specific for the regeneration of particular tissues. On the other hand, this strategy offers a 3D environment that mimics the tissue/ organ of interest in order to test potential therapeutic tools, which goes in accordance with the implementation of the 3R principle (replace, reduce and refine).
Target customer
References
Additional information
CVD graphene growth on copper foils and transfer of CVD graphene to rigid/flexible substrates.
Customer benefits
Adaptable platform for electrical characterization of microelectrodes to meet customer needs
Target customer
Research groups and SMEs
References
The Contact angle service of U7 is specialized in the characterization of surface-liquid interactions at the macro-scale. One can measure contact angle of different liquids and determine the surface free energy of different surfaces under investigation, as well as the wettability properties of different surfaces or different coatings.
Customer benefits
Our Contact angle service benefits from being part of a bioengineering-specialized research centre, providing wide knowledge in the treatment of different surfaces to tailor their properties according to the final bio-application. We offer custom services, assuring close and direct interaction with the client, to meet conclusive results and high-quality needs.
Target customer
Our target customers are researchers in the field of bioengineering or R&D departments of biotech companies which want to test, characterize, or compare different substrates, materials or prototypes.
Additional information
Contact angle measurement of diiodomethane on silicon wafer.
– Synthesis of N-alkyl amino acids and other special amino acids
– Synthesis of peptoids (N-alkylglycine oligomers).
– Synthesis of β-peptide, γ- peptides, β,γ-peptides and α,β-peptides
– Synthesis of peptidomimetics
– Synthesis of hybrid-heterocycle- peptides
Customer benefits
Target customer
References
The service offers custom tailored immunoassay development. It involves designing and optimizing assays for detecting specific analytes (such as proteins, antibodies, or other biomolecules) in biological samples. The service includes identifying necessary reagents, establishing assay parameters, and validating the assay’s performance.
Customer benefits
Target customer
Additional information
Selected references:
Antibody purification involves the selective enrichment or specific isolation of antibodies from various sources, such as serum (for polyclonal antibodies), or cell culture supernatant (for monoclonal antibodies).
The main methods used for antibody purification are:
Customer benefits
Target customer
Additional information
Selected references:
We perform the production of monoclonal antibodies in vitro.
Hybridoma cells are first expanded in culture flask or high density culture devices (for larger amounts of antibody) to get the optimal cell density needed for the production.
The classical medium of production includes fetal calf serum (ultralow IgG, FCS) but our expertise allows us to provide a completely customized service according to your needs, without using FCS.
Supernatant containing the monoclonal antibodies is then periodically collected until the expected quantity of antibodies is obtained.
Depending on the nature of the sample, the expected antibody concentrations are for :
Customer benefits
Target customer
Additional information
Selected references:
