Services

U6-S06. Pulse-free microfluidic system

Pulse-free microfluidic system

Our device offers a pulse-free miniaturized platform designed to manipulate and control small volumes of fluids at the microscale, ranging from microliters to picoliters. The compact size, reduced sample consumption, faster reaction times, and potential for automation make microfluidic devices advantageous for a wide range of scientific and biomedical purposes.

Customer benefits

Offers precise handling of fluids within microchannels or microstructures, enabling various applications such as chemical analysis, biological assays, drug delivery, and point-of-care diagnostics.

Target customer

• Chemical and biochemical companies.
• Biology and chemistry research groups.

U6-S07. Interactions of two biomolecules with respect to binding kinetics and affinity by surface plasmon resonance (SPR).

Interactions of two biomolecules with respect to binding kinetics and affinity by surface plasmon resonance (SPR).

Technically speaking, SPR refers to an optical phenomenon that enables monitoring of changes in refractive index via a quantum mechanical principle.

In a traditional SPR experiment:

• A target is immobilized or captured onto a surface known as a sensor chip.
• A pump is used to flow analytes over the sensor chip.
• An optical measurement system captures changes occurring on the surface of the sensor chip.
• Software plots time-dependent responses in the form of a graph called a sensorgram.

Customer benefits

With SPR, you can determine the rates and affinity of interactions between biomolecules and answer multiple questions using a single instrument.
SPR is the gold standard for analyzing biomolecules, providing:
High quality kinetics (association and dissociation constants, plus equilibrium)

• Real-time data acquisition.
• Label-free analysis.
• Faster, automated experiments.
• Lower sample consumption.

SPR’s flexibility lets you study biomolecular interactions in a wide variety of analytes, from small molecules in drug discovery to peptides, proteins, DNA, viruses, and even whole cells. SPR allows for:

• Simple yes/no binding
• Equilibrium studies
• Complex kinetic analyses
• Thermodynamic analysis
• Concentration determination

Target customer

• Pharmaceutical industry
• Food Industry
• Chemical industry
• Materials research centers

U6-S08. Tangential flow filtration

Tangential flow filtration

Tangential flow filtration (TFF) is a process of separation widely used in bio-pharmaceutical and food industries. It is different from other filtration systems in that the fluid is passed parallel to the filter, rather than being pushed through a membrane perpendicularly which can clog the filter media. This method is preferred for its continuous filtration and reproducible performance. The particles that pass through the membrane, the permeate, are put off to the side, while the rest, the retentate, is recycled back to the feed.

Customer benefits

Tangential flow filtration is used in the following processes:

• Concentration: Increases the concentration of a solution by removing fluids while keeping the solute molecules. This process is done by selecting a filter significantly smaller than the solute molecules to allow for a higher retention of solute molecules.
• Diafiltration: The separation of small and large particles, leaving the smaller particles behind without altering the overall concentration.

Target customer

• Pharmaceutical industry
• Food Industry
• Chemical industry
• Materials research centers

References

M.Köber, et al., J.C.I.S 2023, 631, 202-211

U6-S09. Multimode plate reader

Multimode plate reader

The Infinite 200 PRO is an easy-to-use multimode plate reader family that offers affordable high-performance detection solutions empowered by monochromator- or filter-based technologies. The six new tailored configurations provide excellence in ELISA assays, nucleic acid quantifications, reporter assay technologies, and drug discovery assays including HTRF® and fluorescence polarization.
Dual-mode plate reader with monochromator-based optics for absorbance and sensitive fluorescence (top and bottom reading) applications. Your adjustable tool, even for low concentration nucleic acid and protein quantification.
The Infinite M Nano+ has an excitation monochromator optimized for wavelength accuracy and precision, ensuring excellent performance for every absorbance and fluorescence assay.Engineered for absorbance and fluorescence measurements, the system’s highly sensitive Quad4 Monochromators™ minimize stray light, delivering exceptional flexibility with sensitivity levels close to comparatively priced filter-based instruments.

Customer benefits

Intuitive, workflow-oriented software (i-control) which allows you to create a workflow for each application, using ‘drag and drop’ processing steps to generate your assay protocol, which can be saved for future use.

Highlights:

• Real-time export data
• Extended dynamic range
• Automated z-focusing

Key applications:

• Absorbance-based DNA/RNA quantification and purity checks
• Fluorescence-based DNA/RNA quantification (PicoGreen, RiboGreen®)
• Absorbance-based protein quantification (BCA, Bradford, Lowry, etc.)
• Fluorescence-based protein quantification (eg. NanoOrange®)
• Absorbance- and fluorescence-based ELISAs600 nm growth curves (bacteria, yeast)
• Enzyme kineticsCompound characterization

Target customer

• Pharmaceutical industry
• Food Industry
• Chemical industry
• Materials research centers