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Preclinical validation bioimaging - Services

Preclinical validation bioimaging – Services

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U25-S07. Focused Microwave Fixation System (Onsite&Remote) OUTSTANDING

Focused Microwave Fixation System (Onsite&Remote) OUTSTANDING

Muromachi Focused Microwave Fixation System 5KW-6402C. The system is configured to mouse (TAW-174A Applicator Head for WJM-28 Mouse Holder). Capable of fast euthanization (miliseconds range) of mice, and also to halt postmortem metabolism in cell suspensions and biopsy samples, allowing further examination without the need of low temperatures to avoid postmortem changes.

Customer benefits

Halting postmortem metabolism may allow for different long-term studies such as 13C NMR (natural abundance), 2D NMR acquisitions, and also to use physiological temperatures without any postmortem deterioration. Still, the halted sample is still valid for histopathological examination if needed.

Target customer

Customers that work with systems subjected to fast postmortem changes which could make detailed studies challenging without the use of extreme, non-physiological conditions.

References

  • Delgado-Goñi T, Campo S, Martín-Sitjar J, Cabañas ME, San Segundo B, Arús C. Assessment of a 1H high-resolution magic angle spinning NMR spectroscopy procedure for free sugars quantification in intact plant tissue. Planta. 2013 Aug;238(2):397-413. doi: 10.1007/s00425-013-1924-y. Epub 2013 Jul 4. PMID: 23824526.
  • Davila M, Candiota AP, Pumarola M, Arus C. Minimization of spectral pattern changes during HRMAS experiments at 37 degrees celsius by prior focused microwave irradiation. MAGMA. 2012 Oct;25(5):401-10. doi: 10.1007/s10334-012-0303-1. PMID: 22286777.
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U25-S08. NMR consultancy for processing and interpreting data (Onsite&Remote)

NMR consultancy for processing and interpreting data (Onsite&Remote)

Possibility of requesting expert advice and guidance while processing and interpreting MR data, especially at the preclinical and clinical levels.

Customer benefits

Customers not willing to install and proceed with a learning curve for using specific software can get expert advice and guidance on metabolite significance, interpretation and meaning.

Target customer

Researchers or companies dealing with MR datasets.

References

El-Abtah ME, Wenke MR, Talati P, Fu M, Kim D, Weerasekera A, He J, Vaynrub A, Vangel M, Rapalino O, Andronesi O, Arrillaga-Romany I, Forst DA, Yen YF, Rosen B, Batchelor TT, Gonzalez RG, Dietrich J, Gerstner ER, Ratai EM. Myo-Inositol Levels Measured with MR Spectroscopy Can Help Predict Failure of Antiangiogenic Treatment in Recurrent Glioblastoma. Radiology. 2022 Feb;302(2):410-418. doi: 10.1148/radiol.2021210826. Epub 2021 Nov 9. PMID: 34751617; PMCID: PMC8805659.

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U25-S09. Access to specific software and database (Remote) OUTSTANDING

Access to specific software and database (Remote) OUTSTANDING

Possibility of access to specific software developed in-house (postprocessing of MR spectroscopy data, conversion of spectroscopic data to canonical format, software for automated classification of MR spectroscopic data, decision support systems), provided disclaimer and agreement are signed. Databases with patient MR imaging and spectroscopic data, as well as epidemiological data from two multicentric european projects.

Customer benefits

Curated databases with a high quality level data for further studies. Software no currently available in public repositories. Interaction with researchers specialized in MR data.

Target customer

Customers willing to apply automated classification to their MR spectroscopic data, or willing to apply their methods to different clinically sound datasets.

References

  • Ungan G, et al. Using Single-Voxel Magnetic Resonance Spectroscopy Data Acquired at 1.5T to Classify Multivoxel Data at 3T: A Proof-of-Concept Study. Cancers (Basel). 2023 Jul 21;15(14):3709. doi: 10.3390/cancers15143709. PMID: 37509372; PMCID: PMC10377805.
  • Hernández-Villegas Y, et al. Extraction of artefactual MRS patterns from a large database using non-negative matrix factorization. NMR Biomed. 2022 Apr;35(4):e4193. doi: 10.1002/nbm.4193. Epub 2019 Dec 2. PMID: 31793715.
  • Hellström J, et al. Evaluation of the INTERPRET decision-support system: can it improve the diagnostic value of magnetic resonance spectroscopy of the brain? Neuroradiology. 2019 Jan;61(1):43-53. doi: 10.1007/s00234-018-2129-7. Epub 2018 Nov 15. PMID: 30443796; PMCID: PMC6336758.
  • Julià-Sapé M, et al. Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomes. NMR Biomed. 2016 Mar;29(3):371. doi: 10.1002/nbm.3483. Epub 2015 Dec 22. Erratum for: NMR Biomed. 2015 Dec;28(12):1772-87. Tate, Rosemary A [Corrected to Tate, A Rosemary]. PMID: 26915795.
  • Mocioiu V, et al. From raw data to data-analysis for magnetic resonance spectroscopy–the missing link: jMRUI2XML. BMC Bioinformatics. 2015 Nov 9;16:378. doi: 10.1186/s12859-015-0796-5. PMID: 26552737; PMCID: PMC4640235.
  • Ortega-Martorell S, et al. SpectraClassifier 1.0: a user friendly, automated MRS-based classifier-development system. BMC Bioinformatics. 2010 Feb 24;11:106. doi: 10.1186/1471-2105-11-106. PMID: 20181285; PMCID: PMC2846905.
  • Pérez-Ruiz A, et al. The INTERPRET Decision-Support System version 3.0 for evaluation of Magnetic Resonance Spectroscopy data from human brain tumours and other abnormal brain masses. BMC Bioinformatics. 2010 Nov 29;11:581. doi: 10.1186/1471-2105-11-581. PMID: 21114820; PMCID: PMC3004884.
  • Luts J, et al. A combined MRI and MRSI based multiclass system for brain tumour recognition using LS-SVMs with class probabilities and feature selection. Artif Intell Med. 2007 Jun;40(2):87-102. doi: 10.1016/j.artmed.2007.02.002. Epub 2007 Apr 26. PMID: 17466495.
  • Julià-Sapé M, et al. A multi-centre, web-accessible and quality control-checked database of in vivo MR spectra of brain tumour patients. MAGMA. 2006 Feb;19(1):22-33. doi: 10.1007/s10334-005-0023-x. Epub 2006 Feb 14. PMID: 16477436.

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U24-S02. Medical Imaging for Minimally Invasive Surgery (Onsite&Remote) OUTSTANDING

Medical Imaging for Minimally Invasive Surgery

Advancements in medical technologies have enabled the development and regular use of minimally invasive procedures, which could also be termed image-guided surgery. A platform that can integrate the different imaging techniques is pivotal to aid their development.
NANBIOSIS Unit 24 has medical grade imaging (i.e. Cardiac Magnetic Resonance including delayed enhancement, high performance ultrasound systems, flat panel fluoroscopes, intravascular optical coherence tomography) integrated in a surgical environment, so that these technologies are available for comprehensive follow up of interventions or new surgical approaches. Generally, image acquisition is performed at baseline and serially during the predetermined duration of the study in order to assess the effectiveness of these surgeries on measurable endpoints to document improvement.

Customer benefits

The studies are tailored to the needs of each specific candidate intervention, can be implemented with different follow-up times and can be performed under regulatory requirements, since the performing institution is Certified for Good Laboratory Practices.
Thus the Service can be provided as proof-of-concept studies, full safety and efficacy or under GLPs to meet regulatory agencies’ guidelines and assure clinical translation, so that the customers can take their therapy to a clinical trial faster and more efficiently, thanks to the full range of capabilities offered in this service.

Target customer

The offered service can be of interest to scientists from academia willing to test a possible surgery and perform serial follow up of its outcomes, early-stage medical professionals requiring training in minimally invasive surgery, late-stage surgeons that need to test an idea for an improved surgical approach, commercial companies that need to test the implantation of a device and its effect under GLP studies to commercialize their product.

References

  • Lucas-Cava V, Sánchez-Margallo FM, Dávila-Gómez L, Lima-Rodríguez JR, Sun F. Prostatic artery occlusion versus prostatic artery embolisation for the management of benign prostatic hyperplasia: early results in a canine model. Br J Radiol. 2022 Aug 1;95(1136):20220243. doi: 10.1259/bjr.20220243. Epub 2022 Jul 7. PMID: 35762334; PMCID: PMC10162044.
  • Sánchez-Margallo JA, Tas L, Moelker A, van den Dobbelsteen JJ, Sánchez-Margallo FM, Langø T, van Walsum T, van de Berg NJ. Block-matching-based registration to evaluate ultrasound visibility of percutaneous needles in liver-mimicking phantoms. Med Phys. 2021 Dec;48(12):7602-7612. doi: 10.1002/mp.15305. Epub 2021 Oct 31. PMID: 34665885; PMCID: PMC9298012.
  • Sánchez-Margallo FM, Veloso Brun M, Sánchez-Margallo JA. Identification of intra-abdominal lymphatics in canine carcasses by laparoscopic fluorescence lymphography with intradermal and intrapopliteal ICG administration. PLoS One. 2020 Nov 12;15(11):e0241992. doi: 10.1371/journal.pone.0241992. PMID: 33180854; PMCID: PMC7660503.
  • Sánchez-Peralta LF, Picón A, Sánchez-Margallo FM, Pagador JB. Unravelling the effect of data augmentation transformations in polyp segmentation. Int J Comput Assist Radiol Surg. 2020 Dec;15(12):1975-1988. doi: 10.1007/s11548-020-02262-4. Epub 2020 Sep 28. PMID: 32989680; PMCID: PMC7671995.
  • Crisostomo V et al. Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells. Stem Cell Res Ther. 2019 May 31;10(1):152. doi: 10.1186/s13287-019-1237-6. PMID: 31151405; PMCID: PMC6544975.
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U23-S03. Micromanipulation and microinjection

Micromanipulation and microinjection

Within the Assisted Reproduction Unit we have a laboratory equipped with two micromanipulation and microinjection equipment that allows us to inject the sperm into the cytoplasmic cavity of the oocyte (ICSI), in order to carry out fertilization. The advantage that this equipment offers is that it allows us to carry out in vitro fertilization without having to have a large number of sperm and oocytes. Furthermore, to be able to carry out this technique with oocytes from different animal species, we have a piezoelectric device to perform this intracytoplasmic injection without damaging the oocyte of the specific animal species.

Customer benefits

Having these micromanipulation and microinjection equipment allows us to offer this service to embryologists who wish to train in this technique and acquire the necessary skills to be able to carry out this technique in the human clinic. In addition, the implementation of this ICSI technique and the handling and use of micromanipulators and microinjectors allows for practical training for master’s students and specialized courses in human or animal assisted reproduction.
Because our laboratory is one of the few that researches assisted reproduction with animal models and has all this equipment, human reproduction clinics that want to perform tests with animal oocytes or embryos can perform their tests.
In our laboratory, since experiments can only be carried out with animal species, so our laboratory is suitable for it. In addition, the studies can also be carried out under regulatory requirements, since the institution that performs them is certified in Good Laboratory Practices.
In this way, preclinical studies can be carried out in animal models in compliance with the strict guidelines of the regulatory agencies, ensuring the reliability and traceability of all the results and tests carried out in its different services.

Target customer

This service can provide assistance to all those Human Reproduction companies and clinics that want to carry out in vitro fertilization studies using Micromanipulation and microinjection techniques of mouse embryos or other animal species, since we have a piezoelectric system that facilitates this process without damaging the oocyte.

Additional information

  • Comparative pilot study of surgical activation vs application of platelet-rich plasma on ovarian function in an ovine animal model. P33. S Sánchez-Mateos, F Fabregues, E Párraga-Ros, I S Alvarez, J A Domínguez, M Méndez, J Ferreri, F M Sánchez Margallo.
    British Journal of Surgery, Volume 111, Issue Supplement_1, February 2024, znae018.033, https://doi.org/10.1093/bjs/znae018.033
  • Optimizations of an ovum pick up protocol in Donkey.
    Abstract publicado en la revista: Anim Reprod. 2022;19(2 spe):e22177
    https://www.animal-reproduction.org/journal/animreprod/article/62fe8d1fa9539502764c9db4
  • Supplementation of culture medium with quercetin improves mouse blastocyst quality and increases the expression of HIF-1α protein Hernández, Nuria; Sánchez-Mateos, Soledad; López-Morató, Marta; Sánchez-Margallo, Francisco; Álvarez, Ignacio.
    Zygote, 2023 Feb 27:1-12. https://doi:10.1017/S0967199423000060
  • Effect of the addition of 4OHE2 and quercetin in culture media on ROS levels and gene expression in mouse blastocysts
    Hernández, Nuria; Sánchez-Mateos, Soledad; López-Morató, Marta; Sánchez-Margallo, Francisco; Álvarez, Ignacio.
    Reproduction. Fertility and Development Sep;34(15):980-990
    https://doi.org/10.1071/RD22041
  • 4-Hydroxyestradiol improves mouse embryo quality, epidermal growth factor-binding capability in vitro, and implantation rates. Hernández N, López-Morató M, Perianes MJ, Sánchez-Mateos S, Casas-Rua V, Domínguez-Arroyo JA, Sánchez-Margallo FM, Álvarez IS.
    Mol Hum Reprod. Vol 27 (2) 2021 Nov 25:gaaa075.
    https://doi.org/10.1093/molehr/gaaa075
  • Histological cut of a paraffin-embedded blastocyst: optimized protocol for murine blastocysts.
    Alejandra Uson; Marta López-Morató; José Mijares; Soledad Sánchez-Mateos; Francisco Sánchez- Margallo; Ignacio Álvarez; Nuria Hernández, MSc
    Methods X. vol 7, pp:1-9; 2020, 100767
    https://doi.org/10.1016/j.mex.2019.12.008
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U23-S02. Embryo culture media viability studies

Embryo culture media viability studies

Through this service, and through the time-lapse incubator that we have, embryonic development studies can be carried out by enriching the culture media with different compounds or additives to later verify which of them produces better embryonic development and better quality of the embryos, through viability and embryokinetic studies.

Customer benefits

Because our laboratory is one of the few that does research in assisted reproduction with animal models and has all this equipment, in addition to a bank of gametes and cryopreserved embryos, human reproduction clinics that wish to carry out tests with culture methods for oocytes or embryos, they can only be done with animal species, so our laboratory is suitable for this. In addition, the studies can also be carried out under regulatory requirements, since the institution that carries them out is certified in Good Laboratory Practices.

In this way, preclinical studies can be carried out in animal models in compliance with the strict guidelines of the regulatory agencies, ensuring the reliability and traceability of all the results and tests carried out in its different services.

Target customer

This unit can provide services to all those companies that want to carry out quality control for Human Reproduction clinics, studies of in vitro fertilization and viability of embryo culture media, of mouse embryos or other animal species, whether that we have piezo electric. Furthermore, as we have a bank of cryopreserved mouse oocytes and embryos, any company that needs to have a large number of these gametes and embryos can benefit from this service.

Additional information

  • Comparative pilot study of surgical activation vs application of platelet-rich plasma on ovarian function in an ovine animal model. P33. S Sánchez-Mateos, F Fabregues, E Párraga-Ros, I S Alvarez, J A Domínguez, M Méndez, J Ferreri, F M Sánchez Margallo.
    British Journal of Surgery, Volume 111, Issue Supplement_1, February 2024, znae018.033, https://doi.org/10.1093/bjs/znae018.033
  • Optimizations of an ovum pick up protocol in Donkey.
    Abstract publicado en la revista: Anim Reprod. 2022;19(2 spe):e22177
    https://www.animal-reproduction.org/journal/animreprod/article/62fe8d1fa9539502764c9db4
  • Supplementation of culture medium with quercetin improves mouse blastocyst quality and increases the expression of HIF-1α protein Hernández, Nuria; Sánchez-Mateos, Soledad; López-Morató, Marta; Sánchez-Margallo, Francisco; Álvarez, Ignacio.
    Zygote, 2023 Feb 27:1-12. https://doi:10.1017/S0967199423000060
  • Effect of the addition of 4OHE2 and quercetin in culture media on ROS levels and gene expression in mouse blastocysts
    Hernández, Nuria; Sánchez-Mateos, Soledad; López-Morató, Marta; Sánchez-Margallo, Francisco; Álvarez, Ignacio.
    Reproduction. Fertility and Development Sep;34(15):980-990
    https://doi.org/10.1071/RD22041
  • 4-Hydroxyestradiol improves mouse embryo quality, epidermal growth factor-binding capability in vitro, and implantation rates. Hernández N, López-Morató M, Perianes MJ, Sánchez-Mateos S, Casas-Rua V, Domínguez-Arroyo JA, Sánchez-Margallo FM, Álvarez IS.
    Mol Hum Reprod. Vol 27 (2) 2021 Nov 25:gaaa075.
    https://doi.org/10.1093/molehr/gaaa075
  • Histological cut of a paraffin-embedded blastocyst: optimized protocol for murine blastocysts.
    Alejandra Uson; Marta López-Morató; José Mijares; Soledad Sánchez-Mateos; Francisco Sánchez- Margallo; Ignacio Álvarez; Nuria Hernández, MSc
    Methods X. vol 7, pp:1-9; 2020, 100767
    https://doi.org/10.1016/j.mex.2019.12.008
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U23-S01. In vitro fertilisation studies and embryo culture media viability

In vitro fertilisation studies and embryo culture media viability

Through this service, in vitro fertilization processes can be carried out, including IVF and ICSI, of oocytes and sperm from different animal species, including mice, which are the animal species we mainly work with. To carry out this fertilization we have cabins, heated laminar flow, with stereomicroscopes included, plates, incubators with different gas systems and in order to evaluate the development of the embryos in real time we have recently incorporated a time lapse incubator, which allows us to carry out embryokinetic studies without having to remove the plates and the embryo from the incubator which improves the quality and viability of the embryo.

Customer benefits

Because our laboratory is one of the few that does research in assisted reproduction with animal models and has all this equipment, in addition to a bank of gametes and cryopreserved embryos, human reproduction clinics that wish to carry out tests with culture methods for oocytes or embryos, they can only be done with animal species, so our laboratory is suitable for this. In addition, the studies can also be carried out under regulatory requirements, since the institution that carries them out is certified in Good Laboratory Practices.
In this way, preclinical studies can be carried out in animal models in compliance with the strict guidelines of the regulatory agencies, ensuring the reliability and traceability of all the results and tests carried out in its different services.

Target customer

This unit can provide services to all those companies that want to carry out quality control for Human Reproduction clinics, studies of in vitro fertilization and viability of embryo culture media, of mouse embryos or other animal species, whether that we have piezo electric. Furthermore, as we have a bank of cryopreserved mouse oocytes and embryos, any company that needs to have a large number of these gametes and embryos can benefit from this service.

Additional information

  • Comparative pilot study of surgical activation vs application of platelet-rich plasma on ovarian function in an ovine animal model. P33. S Sánchez-Mateos, F Fabregues, E Párraga-Ros, I S Alvarez, J A Domínguez, M Méndez, J Ferreri, F M Sánchez Margallo.
    British Journal of Surgery, Volume 111, Issue Supplement_1, February 2024, znae018.033, https://doi.org/10.1093/bjs/znae018.033
  • Optimizations of an ovum pick up protocol in Donkey.
    Abstract publicado en la revista: Anim Reprod. 2022;19(2 spe):e22177
    https://www.animal-reproduction.org/journal/animreprod/article/62fe8d1fa9539502764c9db4
  • Supplementation of culture medium with quercetin improves mouse blastocyst quality and increases the expression of HIF-1α protein Hernández, Nuria; Sánchez-Mateos, Soledad; López-Morató, Marta; Sánchez-Margallo, Francisco; Álvarez, Ignacio.
    Zygote, 2023 Feb 27:1-12. https://doi:10.1017/S0967199423000060
  • Effect of the addition of 4OHE2 and quercetin in culture media on ROS levels and gene expression in mouse blastocysts
    Hernández, Nuria; Sánchez-Mateos, Soledad; López-Morató, Marta; Sánchez-Margallo, Francisco; Álvarez, Ignacio.
    Reproduction. Fertility and Development Sep;34(15):980-990
    https://doi.org/10.1071/RD22041
  • 4-Hydroxyestradiol improves mouse embryo quality, epidermal growth factor-binding capability in vitro, and implantation rates. Hernández N, López-Morató M, Perianes MJ, Sánchez-Mateos S, Casas-Rua V, Domínguez-Arroyo JA, Sánchez-Margallo FM, Álvarez IS.
    Mol Hum Reprod. Vol 27 (2) 2021 Nov 25:gaaa075.
    https://doi.org/10.1093/molehr/gaaa075
  • Histological cut of a paraffin-embedded blastocyst: optimized protocol for murine blastocysts.
    Alejandra Uson; Marta López-Morató; José Mijares; Soledad Sánchez-Mateos; Francisco Sánchez- Margallo; Ignacio Álvarez; Nuria Hernández, MSc
    Methods X. vol 7, pp:1-9; 2020, 100767
    https://doi.org/10.1016/j.mex.2019.12.008
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U21-S01. In vivo Efficacy Assays of drugs, nanomedicines, biomaterials and others

In vivo Efficacy Assays of drugs, nanomedicines, biomaterials and others

Preclinical studies for the evaluation of medical treatments, medical devices and surgical techniques in a controlled environment prior to their application in patients.
Conducting studies -both in human and veterinary medicine- of in vitro toxicity, in vivo toxicity, tolerance, pharmacodynamics, test product administration and procurement of non-clinical specimens, biocompatibility of medical devices, murine model embryo transfers, intracytoplasmic microinjection, oocyte vitrification, measurement and analysis of Natural Killer (NK) cell samples, seminogram and semen studies.
Creation of experimental animal models of various human diseases such as diabetes, obesity, hypercholesterolemia, hypertriglyceridemia, acute and chronic myocardial infarction, prostatic hyperplasia, ulcers, pleural adhesions, constrictive pericarditis and abdominal aortic aneurysm, among others. Possibility of working with a variety of animal species: rodents, rabbits, dogs, cats, pigs and sheep.
Application of experimental animal models for research in several longitudinal areas such as cardiovascular, hepatic and digestive, respiratory and systemic diseases, endocrinology and urology, gynecological and reproductive diseases, prostheses, among others.

Customer benefits

Preclinical studies can be carried out under good laboratory practice (GLP 23.05/001 AEMPS), optimal for reporting to the AEMPS, EMA and FDA.
In vivo toxicity, tolerance, pharmacodynamics, test product administration and non-clinical specimen collection and biocompatibility studies of medical devices are carried out according to OECD decision C(89)87.
Registered facilities for the use and breeding of experimental animals, which has an Animal Welfare Ethics Committee and a pharmacy and formulation laboratory.

Target customer

Entities involved in the research, development or commercialization of medical devices or treatments such as pharmaceutical and biotechnology companies, academic and scientific researchers, medical device companies, research institutions and laboratories, and governmental and regulatory organizations.

Additional information

  • Jiménez-Holguín J, Lozano D, Saiz-Pardo M, de Pablo D, Ortega L, Enciso S, Fernández-Tomé B, Díaz-Güemes I, Sánchez-Margallo FM, Portolés MT, Arcos D. Osteogenic-angiogenic coupled response of cobalt-containing mesoporous bioactive glasses in vivo. Acta Biomater. 2024 Mar 1;176:445-457. doi: 10.1016/j.actbio.2024.01.003. Epub 2024 Jan 6. PMID: 38190928.
  • Lucas-Cava V, Sánchez-Margallo FM, Moreno-Lobato B, Dávila-Gómez L, Lima-Rodríguez JR, García-Martínez V, López-Sánchez C, Sun F. Prostatic artery occlusion: initial findings on pathophysiological response in a canine prostate model. Transl Androl Urol. 2022 Dec;11(12):1655-1666. doi: 10.21037/tau-22-423. PMID: 36632152; PMCID: PMC9827397.
  • Arcos D, Gómez-Cerezo N, Saiz-Pardo M, de Pablo D, Ortega L, Enciso S, Fernández-Tomé B, Díaz-Güemes I, Sánchez-Margallo FM, Casarrubios L, Feito MJ, Portolés MT, Vallet-Regí M. Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions. Acta Biomater. 2022 Oct 1;151:501-511. doi: 10.1016/j.actbio.2022.07.067. Epub 2022 Aug 3. PMID: 35933104.
  • Soria F, de La Cruz JE, Caballero-Romeu JP, Pamplona M, Pérez-Fentes D, Resel-Folskerma L, Sanchez-Margallo FM. Comparative assessment of biodegradable-antireflux heparine coated ureteral stent: animal model study. BMC Urol. 2021 Feb 28;21(1):32. doi: 10.1186/s12894-021-00802-x. PMID: 33639905; PMCID: PMC7916282.
  • Marinaro F, Casado JG, Blázquez R, Brun MV, Marcos R, Santos M, Duque FJ, López E, Álvarez V, Usón A, Sánchez-Margallo FM. Laparoscopy for the Treatment of Congenital Hernia: Use of Surgical Meshes and Mesenchymal Stem Cells in a Clinically Relevant Animal Model. Front Pharmacol. 2020 Sep 25;11:01332. doi: 10.3389/fphar.2020.01332. PMID: 33101010; PMCID: PMC7546355.
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U20-S01. Non-invasive optical imaging (bioluminescence and fluorescence) (Remote) OUTSTANDING

The service includes de use of singular equipment for optical in vivo imaging (IVIS® Spectrum and Macrofluo) for the acquisition and quantification of bioluminescent and/or fluorescent images in vitro, in vivo or ex vivo.

Quantification services, as well as support on the analysis of obtained images by specialized personnel is also included.

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U20-S02. Animal models in oncology (Remote) OUTSTANDING

The unit/platform has strong background in oncology and counts with different type of cancer mouse models, all of them monitorable by means of bioluminescence imaging. They include subcutaneous models in a great variety of cancer types (prostate, colon, breast, pancreas, kidney, etc.) and also orthtopic and experimental metastasismodels.

The unit/platform can also set-up and validate novel xenograft models upon request.

 List of available models

  • Subcutaneous models (different cell lines and cancer types)
  • Orthotopic models:
    • Intraprostatic
    • Intramammary (i.m.f.p.)
    • Stereotactic
    • Ceccum
    • Intrapulmonar
  • Experimental metastases:
    • Intracardiac (bone metastases)
    • Intravenous (lung metastases)
    • Intraportal (liver metastases)
  • Spontaneous metastases
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