MRSI-based generation of nosological images for noninvasive therapy response assessment in preclinical GBM
Nuria Arias Ramos from GABRMN-UAB, research group coordinator of Unit 25 of NANBIOSIS, presented on January 30th, an oral communication at the youngSMIN | young Spanish Molecular Imaging Network Meeting.
The title of the communication is “Multi slice MRSI-based generation of nosological images for noninvasive therapy response assessment in preclinical GBM”, written by Nuria Arias-Ramos, SilviaLope-Piedrafita, Victor Mocioiu, Margarida Julià-Sapé, Carles Arús and Ana Paula Candiota.
The work is basically centered in extending the preliminary GABRMN study based on MRSI acquired in a preclinical glioblastoma (GB), both under treatment and control, with pattern recognition and source extraction for noninvasive therapy response assessment. The preliminary study was performed in a single tumoral slice, but the GB is a well-known heterogeneous tumor and also presents heterogenous response to treatment, so the multislice acquisition was an important step in order to characterize therapy response assessment as a whole, not centered in a single slice. Tumors were stratified in no response, partial response and high response after calculating the percentage of the ‘responding’ part of the tumor, and histopathological studies for correlation are in progress.
The MRSI acquisition and processing steps were performed in NANBIOSIS facility U25.
