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New 3D culture device to better understand how tumours work

Scientist of NANBIOSIS in collaboration with other CIBER-BBN researchers have developed a sophisticated microfluidic biomedicine device capable of reproducing in vitro and by 3D bioprinting the complexity of different tumour types. This device allows tumour cells to grow in a 3D environment where nutrients and oxygen are supplied in a controlled way through small capillaries, thus mimicking the body’s own blood vessels.

Thanks to this new technology, it is now possible to reproduce in a controlled way all the processes of the tumour environment, which could help to develop new treatments and combinations of drugs that are more effective for the treatment of these tumours.

In this study, published in Scientific Reports, have participated researchers from the Group of Applied Mechanics and Bioengineering (AMB) of the University of Zaragoza , which coordinates Unit 13 of NANBIOSIS .

Article of reference:

Development and characterization of a microfluidic model of the tumour microenvironment.Jose M. Ayuso, María Virumbrales-Muñoz, Alodia Lacueva, Pilar M. Lanuza, Elisa Checa-Chavarria, Pablo Botella, Eduardo Fernández, Manuel Doblare, Simon J. Allison, Roger M. Phillips, Julián Pardo, Luis J. Fernandez e Ignacio Ochoa. Scientific Reports. 10.1038/srep36086

New 3D culture device to better understand how tumours work
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4 Units of NANBIOSIS hosted in three Universities among the 200 best in the world in science.

The University of Zaragoza is one of the 200 best universities in the world in science research, according to the latest Shanghai ranking of 2016 in a specific analysis by macro areas.

In order to elaborate this ranking by macroareas indicators such as the number of students and professors who have obtained the Nobel prize or Fields medal, the number of researchers highly cited in the scientific literature, the number of scientific articles indexed in the Science Citation Index and the Percentage of articles published in the most cited 20% scientific journals are used.

Only six Spanish universities are among the 200 best in the world in the field of science, such as the Autonomous University of Madrid, University of Barcelona, University of Santiago de Compostela, Polytechnic University of Valencia, University of Valencia and Zaragoza.

The list of the world’s top 200 universities in science is headed by American universities in Berkeley (California), Stanford, Princeton, Harvard, the Massachusetts Institute of Technology and California, which rank the top six. In the seventh one appears the first European university, Cambridge, followed by the one of Tokyo, Technological Institute of Switzerland and the University of Los Angeles.

NANBIOSIS contributes to this success through the elite researchers that coordinate three of its Units located in the University of Zaragoza: Unit 9 that offers services for sciences research as Synthesis of Nanoparticles biomedicine, micronanotechnology or microfluidics biomedicine, Unit 13 with services as tissue and biomaterial characterization or mechanical tests of tissues and Unit 27 which offers services for sciences research on biomedical computer simulation, modelling of biomedical systems or large simulation multicore and multiserver, among other aspects.

In addition, the Polytechnic University of Valencia and the University of Valencia provides the scientific management and part of the equipment to Unit 26 of NANBIOSIS that offers services for research as molecular imaging metabolomics by NMR or metabolic profiling of biofluids by NMR

Three Universities among the 200 best in the world in science, hosting 4 Units of NANBIOSIS.
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