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Women in NANBIOSIS part 6: A conversation with Ana Mincholé on unlocking the heart’s secrets

Dr. Mincholé discusses cardiac risk assessment, gender challenges in science, and the transformative potential of Digital Twins in healthcare research.

This is part of a series of interviews to several female researchers within the context of International Day of Women and Girls in Science 2024 and Woman’s Day 2024. For more interviews, visit our news section here.

March 2024, I3A-Unizar, Zaragoza (Spain)

The meeting room of the High Performance Computing cluster is a comfortable place. A whiteboard full of diagrams occupies a good portion of one of the side walls, creating a welcoming atmosphere where complex concepts become accessible. In stark contrast, a long table is presided over by a large screen and a video call system, making it clear that the boundaries of this place extend beyond its modest size.

The meeting has just ended. It has been intense. In it, the members of NANBIOSIS Unit 27 have given us a comprehensive update on their work. Although our background is more focused on the biomedical aspect, the explanation has been so didactic that we have ended up feeling like part of something much, much larger. Theirs is a work full of versatility and possibilities, only limited by the immense computing power of their machines and the indisputable brilliance of their staff.

Ana Mincholé, one of the team members, waits for the interview to begin. She has already expressed her nervousness to me but, without intending to question her word, I believe she underestimates herself. She was able to open our eyes during that complex meeting, along with the rest of the team, allowing an audience with little computational background to understand the endless possibilities of their equipment. This is a piece of cake for her.

The interview begins.

What motivated you to choose a career in science?

“I’m not sure if science chose me, or if humanities rejected me. I’ve always found physics and mathematics much more entertaining than humanities subjects.”

Interesting… Usually children tend to think that mathematics is very difficult, that physics is very boring… etc.

“It’s a bit strange. I felt more creative solving problems and looking for different ways to solve them, rather than in humanities subjects that I… um (laughs), when I thought I had done something great, they would tell me that… well, that it wasn’t (laughs again). I always knew that I was more into science than humanities disciplines. I liked it more.”

From the beginning, you felt that what they were teaching you in mathematics and physics was more natural for you.

“Yes, the typical problems such as ‘a train leaves from somewhere at such a speed of…’, I found them much more entertaining.”

Could you share with us a little about your research area and the projects you are currently working on?

“In general, my research focuses on the assessment of sudden cardiac death risk in patients with cardiovascular diseases. We work with patients who have suffered heart attacks, cardiomyopathies (heart defects), or patients with bradycardia who need pacemakers. We evaluate the risks using the electrocardiogram, which measures the electrical activity of the heart, and in my case, also through computational models. These are virtual replicas of a patient’s heart that include all their clinical information, and you can evaluate them under different scenarios and see how they respond.”

Does this have to do with the ‘Digital Twins’? That is, replicating on a computer what happens to a person and seeing how the conditions you apply affect them.

“Yes, that’s it. In the case of the heart, for example, we can emulate cardiac anatomy through magnetic resonance images, then you can include fibrotic areas, infarcted areas, electrical dynamics… and with all this, you can simulate the electrical activity of a heart.”

So, not only can you mimic a healthy heart, but also a diseased one.

“That’s right. In hearts, there are always some areas that activate spontaneously. Normally this poses no danger, but in those hearts that already have some arrhythmogenic substrate, meaning that they have some type of previous pathology such as infarcted or fibrotic areas, those activations can cause an arrhythmia.”

What have been the greatest challenges you have faced as a woman in the field of scientific research?

“What a complicated question! There are so many challenges you face simply as a researcher… Perhaps more as a woman? I could highlight that I am a mother of two children, and research is always something that is constantly moving. Facing maternity, personally, I had a lot of plans and I told myself that I wouldn’t leave anything behind. I believed that, as soon as I felt better, I would start doing things, reading articles… but life with a newborn is what it is, and in the end, you don’t do it. And you have that fear and you start to wonder things such as ‘What happened during all this time?’, ‘Will I be able to catch up?’. “

So, I understand that you think the measures that are already in place are insufficient.

“Of course. The thing is research never stops. Science keeps advancing, with or without you. And although in the end it’s not that big of a deal, it’s a feeling you constantly have. Research is a bit strange: on one hand, you have a lot of flexibility, but at the same time, you never really disconnect. Deadlines come, and if you have to work on the weekend, you do it. Or maybe there is that Tuesday in which nothing has come out right, and at night you keep thinking about why the experiment you did in the morning didn’t work out. You keep coming up with ideas, and never really stop thinking about it.”

It is interesting what you’re saying because that applies to a lot of research fields. One might think that in the case of in silico experiments it would not be as bad as, for example, people working with animal models.

“Well, in our field of in silico experiments, you always encounter an error right on Friday before leaving work (laughs). Although during my master’s, I worked on a more experimental project, and it’s true that it’s a whole different level: If something doesn’t work out, you have to wait until it finishes, and I think in that sense, it’s much more demanding.”

Have you experienced any kind of gender bias or added difficulty in your scientific career? How have you addressed this situation?

“I feel like I haven’t faced a significant bias because of being a woman. Also, I’ve felt supported in all the research groups I’ve been part of. It’s true that in some fields, certain attitudes like paternalism and condescension arise because of being young and a woman. But young people stop being young… and women never stop being women (laughs). In those cases, you have to demonstrate that you know what you know, which adds pressure.”

There are fields and careers where there are many more women than men. This is the case for the more ‘bio’ careers. How do you see parity in your field?

“In my field, there’s quite a gender parity. Moreover, in all the groups I’ve worked with, there’s been a fair balance between men and women. I won’t deny that the further you advance in the research career, the more gender bias there is. Generally, there are more men in leadership positions than women, and women tend to have a harder time too. In my case, I haven’t personally experienced any gender bias. I’m lucky to be able to collaborate with people who add value. And with those who don’t, there’s no need for us to collaborate.”

How do you think these barriers can be overcome?

“Visibility. It has worked in other areas. I, being a bit older, remember not long ago when we had a female Minister of Defense, and there were those who were shocked. And nowadays, we don’t give it importance anymore. The visibility of women in science is constantly increasing. An example is the researcher behind the Oxford/Astra Zeneca COVID vaccine, whose presence in the media was quite prominent. We see it more and more often.”

What advice would you give to young women considering a career in science?

“I would tell them to go for it, that it’s a very rewarding career with plenty of opportunities. Sometimes, I think there’s a lack of female role models in science and also in other sectors. This is because even when there’s a mixed team working behind the scenes, the predominant presence of male figures gives a biased picture. And I believe it’s important to convey that science isn’t just for men.”

“(I) design and work on a research line that combines computational models with cardiac signals and images. This was done with the aim of stratifying arrhythmic risk and understanding its mechanisms.“

—Dr. Ana Mincholé, researcher at Unit 27.

Have you had any ‘Eureka’ moments in your career? What do you consider to be your greatest achievement or contribution in your field on a professional or personal level?

“Luckily in research, you have quite a few ‘Eureka’ moments. And thank goodness for that! Because there are also many frustrating moments that require a lot of effort and work. Thus when something finally works out, it’s very satisfying. But you have to constantly deal with ups and downs.

As for my greatest achievements, at the end of my PhD, we managed to develop a novel biomarker that was closely related to arrhythmic risk. That was a real high. Something more recent could be to design and work on a research line that combines computational models with cardiac signals and images. This was done with the aim of stratifying arrhythmic risk and understanding its mechanisms. I’m not sure if I would define it as an achievement, but it’s a line of work that I’m particularly proud of.”

Where do you see yourself in 5 or 10 years? And where do you see this technology?

“In the future, I imagine Digital Twins technology being more integrated into clinical practice, with tangible benefits for patients. I think, at the moment, it’s more used at the research level and needs better explanation to understand its potential. But I’m convinced that this technology will be very useful in clinical settings, and I would like to be present when that happens.

Digital Twins of the heart are detailed virtual replicas that incorporate clinical information and specific measurements from each patient in addition to how the heart functions. They are very self-explanatory, and they answer the question of ‘why’ something happens, providing possible explanations for what is going on. Although these models are very descriptive, I don’t see them as incompatible with other types of models, such as artificial intelligence-based solely on data.

In the case of Digital Twins, behaviors and dynamics are introduced, making them much more explanatory. Furthermore, they are multiscale models that cover everything from the cellular level to propagation through cardiac tissue and the torso, even simulating the patient’s electrocardiogram. These multiscale models allow for personalized therapies and specific assessment of arrhythmic risk for each individual.”

How do you think we can encourage more women and girls to participate in science?

“I have participated in initiatives that are fantastic for explaining different professional experiences to people who have to choose a career. I also believe that we need to give visibility to science; not only from the perspective of research, but by showing all the possibilities that pursuing a career in science offers. I think, in the end, one has to choose the career they like the most, and then they can always redirect their decisions to work in what motivates them at each stage of life. The important thing is to decide to do things that fulfill you, motivate you, and do them well.

For example, I studied Physics and never imagined doing a PhD. Then, I went on Erasmus, ended up doing a master’s, and during the master’s thesis project, I discovered that biomedical research fascinated me and fulfilled me. So, I ended up doing a PhD. Life takes you places, and the important thing is to do things that bring you fulfillment and that you enjoy.”

Thank you very much Ana for your time.

“Thanks a lot, to you.”

For more interviews like this, visit our news section here.

Additional information:

The goal of NANBIOSIS is to provide comprehensive and integrated advanced solutions for companies and research institutions in biomedical applications. All of this is done through a single-entry point, involving the design and production of biomaterials, nanomaterials, and their nanoconjugates. This includes their characterization from physical-chemical, functional, toxicological, and biological perspectives (preclinical validation).

In order to access our Cutting-Edge Biomedical Solutions, place your request here.

NANBIOSIS has worked with pharmaceutical companies of all sizes in the areas of drug delivery, biomaterials and regenerative medicine. Here are a few of them:

Women in NANBIOSIS part 5: Susana Vílchez and her insights on water-in-water emulsions and gender equality in Science

Dr. Vílchez, our esteemed colloidal chemistry researcher, discusses her focus on water-in-water emulsions and microcoacervates. She highlights gender biases in science and advocates for inclusivity and recognition of women’s contributions.

This is part of a series of interviews to several female researchers within the context of International Day of Women and Girls in Science 2024 and Woman’s Day 2024. For more interviews, visit our news section here.

March 2024, IQAC-CSIC, Barcelona (Spain)

Dr. Susana Vílchez, an esteemed researcher in colloidal chemistry, and the technical and quality manager of Unit 12 of NANBIOSIS, offers a profound insight into her research endeavors and career trajectory. Specializing in the characterization of colloidal systems such as micelles, vesicles, emulsions, and more, her current focus lies on the intriguing realm of water-in-water emulsions and the formation of microcoacervates, serving as a model for membraneless organelles (MLO) by introducing DNA into these emulsions. As we delve into her motivations, achievements, and challenges within the scientific domain, Dr. Vílchez sheds light on the gender biases prevalent in her field and offers invaluable perspectives on fostering gender equality in science. Through her experiences and unwavering dedication, she inspires young women to pursue their scientific aspirations while advocating for broader inclusivity and recognition of women’s contributions in shaping the scientific landscape.

Could you share with us a bit about your research area and the projects you are currently working on?

“My research area is colloidal chemistry, specifically the characterization of colloidal systems such as micelles, vesicles, emulsions, gels, liquid crystals, etc. One of the projects I’m working on involves water-in-water emulsions and the formation of microcoacervates by adding DNA to these emulsions. These microcoacervates can be used as a model for so-called membraneless organelles (MLO).”

What motivated you to choose a career in research?

“Since I was little, I’ve always liked knowing the reason behind things. I remember I really enjoyed a series of cartoons that dealt with the human body, as well as other TV shows like ‘El hombre y la Tierra’  (The Man and the Earth) and ‘El mundo submarino’ (The Underwater World).”

What do you consider to be your greatest achievement or contribution in your field?

“I have contributed to the training of undergraduate and master’s degree students. I have tried to help them see their potential to develop as future scientists.”

Have you experienced any gender bias or added difficulties in your scientific career? How have you addressed this situation?

“Within my area of research, there has been more support for the scientific careers of men than women. Men are attributed greater capability while women are seen as putting in more effort. To address this situation, I have tried to educate myself in areas that help me better develop my work, such as improving my communication skills, learning to manage stress, and becoming more resilient.”

How do you think gender stereotypes in the scientific field can be overcome?

“To overcome gender stereotypes in the scientific field, I believe we should approach the issue as a whole, from all sides. Firstly, we should strive to eliminate bias in education, both at the family level and in primary and secondary education. Secondly, we should avoid perpetuating gender stereotypes through media, social networks, video games, etc.”

What changes would you like to see in the scientific world to promote gender equality?

“I would like to see more support for women’s scientific careers. Despite policies aimed at reducing inequalities between men and women in the scientific world, men still predominantly occupy leadership positions. I would like to see greater inclusion of women to motivate them to pursue their scientific careers.”

“I would advise (young women) to pursue their dreams, to show others what they are capable of, and not to let themselves be underestimated.“

—Dr. Susana Vílchez, technical and quality manager of Unit 12.

What advice would you give to young women who are considering pursuing a career in science?

“I would advise them to pursue their dreams, to show others what they are capable of, and not to let themselves be underestimated. Our goals and purpose in life can be achieved with perseverance and effort.”

How do you think we can encourage more women and girls to participate in science?

“By promoting awareness in schools and high schools about the importance of science for society. I would also advocate for more scientific outreach programs in the media, television, radio, etc. Additionally, I believe it’s crucial to highlight the contributions of women in science, providing girls with female role models in the scientific world.”

For more interviews like this, visit our news section here.

Additional information:

The goal of NANBIOSIS is to provide comprehensive and integrated advanced solutions for companies and research institutions in biomedical applications. All of this is done through a single-entry point, involving the design and production of biomaterials, nanomaterials, and their nanoconjugates. This includes their characterization from physical-chemical, functional, toxicological, and biological perspectives (preclinical validation).

In order to access our Cutting-Edge Biomedical Solutions, place your request here.

NANBIOSIS has worked with pharmaceutical companies of all sizes in the areas of drug delivery, biomaterials and regenerative medicine. Here are a few of them:

Women in NANBIOSIS part 4: María Sancho’s journey from nanomaterials to cancer therapy

Our expert in nanocarriers talks about her journey from biotechnology to cancer therapy, an example of passion and perseverance in science.

February 2024, I3A/CIBER-BBN, Zaragoza (Spain)

The silence of the meeting room is only broken by the constant purring of the heating system. A large square table made of dark wood fills the entire room almost completely. Its dimensions are too extensive for anyone to reach its center. One may wonder, how many passionate conversations about the next step to take in countless research projects have been witnessed by these four walls?

The door swings open briskly, and a familiar face crosses the threshold with a smile. We have shared lab bench in the past, and María, with her memory honed by years of dedication to her craft, remembers that brief period of our lives surprisingly well. We greet each other warmly. She radiates energy and passion for what she does.

The interview begins.

Hello María, tell us a little about yourself.

“My name is María Sancho, I studied a Bachelor’s Degree in Biotechnology at the University of Zaragoza, just the second generation after its implementation. I did my bachelor’s thesis at the Institute of Nanoscience and Materials of Aragon (INMA), and this contact with nanotechnology made me decide to continue expanding my training in this field and try to dedicate myself to science and research. Then I did the Master’s in Nanomaterials, the ‘NanoMat’, at INMA, as it complemented my biochemistry-oriented training very well with the materials aspect of the Master’s.

After I finished both my bachelor’s and master’s thesis at INMA, I had the opportunity to apply for (and obtain) a prestigious State doctoral scholarship with Jesús Santamaría as Principal Investigator. This allowed me to do my thesis here in Zaragoza, which I defended in December 2020. For the past three years, I have been in Milan, at the Mario Negri Institute of Pharmacological Research, with Luisa De Cola. Her outstanding work focuses mainly on nanomaterials, different from those I worked on during my thesis, allowing me to train in a highly complementary area.”

So, you’re currently doing your postdoc in… Italy?

“No, no. I just returned last October, once again, to Jesús Santamaría’s group, with the goal of establishing here in Zaragoza as a researcher… if possible (laughs).”

“I am fortunate to be able to devote myself to something I am passionate about. Research is something I enjoy every day.”

—Dr. María Sancho, Researcher at Unit 9.

What motivated you to choose a career as a researcher?

“Ever since I was very young, I’ve been an inquisitive, curious, and creative person. I got into research spontaneously, although it’s true that in my family we always talked about scientific research, my father was a teacher and a geologist himself. Over time I’ve realized that science has a vocational component, it requires a lot of dedication, but it excites me. During my high school studies, I was clear about choosing the scientific path. After finishing high school, I pursued a degree in Biotechnology, which had been implemented in Zaragoza just a year before. During my studies, I witnessed the significant advances of the great nanotechnological revolution of recent years. My interest grew only stronger and I decided to do my doctoral studies.

In 2016, I obtained a prestigious and competitive contract for the so-called University Professor Training State program ‘FPU’ from the Ministry of Education. This allowed me to carry out my doctoral thesis at the University of Zaragoza, in a leading and excellent research institute like INMA. So, I could say that I didn’t hesitate to start my career as a scientist. During this period, I was fortunate to have thesis supervisors who transmitted their passion and enthusiasm for research to me. This undoubtedly encouraged me to continue developing my scientific career. Today, I can say that I am fortunate to be able to devote myself to something I am passionate about. Research is something I enjoy every day.

Could you share with us a bit about your area of research and the projects you are currently working on?

“In general terms, my research focuses on developing small containers, which we call nanoparticles, with nanometric dimensions. This means that they are much smaller than human cells. Specifically, my project is based on developing nano-containers capable of directing and transporting drugs and anti-tumor molecules in the body. This way, we load these nanoparticles, which have therapeutic properties, inside vesicles produced by our own body, so that they can kill and act against tumor cells. We hope that these nano-containers with therapeutic properties, once injected into the bloodstream, can reach their target cell and then release the drugs loaded inside them. When we take a painkiller for example, only a small part of the drug acts to relieve that headache. In this project, what we aim for is the possibility of using less therapy and directing it selectively to the tumor. In this way, the maximum possible amount of the supplied active compound reaches the cancer cells. Furthermore, by being encapsulated in these nano-containers and selectively reaching tumor cells, it would ensure avoiding side effects and not affecting other organs.”

What have been the greatest challenges you have faced as a woman in your research field?

“From my experience, to this day, I have not faced challenges attributed to gender. I believe the greatest challenges I have encountered have been common to those of my male colleagues, and are linked to being ‘young researchers’. I associate these challenges with the fact that research is not only an occupation of nearly irrelevant importance in Spain, but also one of great uncertainty, and it is not sufficiently recognized. It requires great dedication, many hours of work, sometimes yielding good results, and other times not. Furthermore, there are few and highly competitive State grants in Spain that allow you to dedicate oneself to research continuously and steadily. As you progress in your research career, you spend more time on bureaucracy, seeking funding and more projects. And the truth is that in the vast majority of cases you won’t get them. This derives in less hours in the lab doing the experiments. I believe there are not enough resources available today.”

Have you ever experienced any type of gender bias or added difficulty in your scientific career? How have you addressed this situation?

“From my experience, up to this day, I have not encountered any additional difficulties compared to men. Nor have I experienced any situations of inequality. However, I do believe that all young researchers, in general, both women and men, face significant challenges in advancing and developing their professional careers. In fact, many of the colleagues I encountered while doing my doctoral thesis have been forced to abandon their scientific careers.”

Could you tell us more about your challenges as a young researcher?

“One of the biggest challenges has been having to go abroad to continue my scientific career. This requires great effort and dedication. Already during my doctoral thesis, I undertook two stays abroad. One of them was for three months at ETH Zurich. The other one lasted for two months at Politecnico di Milano. After completing my doctoral thesis in 2020, I followed the advice of my supervisor to go abroad for at least two more years to continue my postdoctoral career. It was not an easy decision, as I embarked on my journey amid the COVID pandemic, but I had the opportunity to get a job interview with Luisa De Cola, the leader of a globally renowned group.

Although it has been a path full of changes and uncertainty, I don’t feel like I have had to give up anything I wanted in order to pursue my work. However, it’s true that research has taken my time away from other activities. I have probably missed out on doing some things. I have spent two and a half years away from my family and friends in order to continue my education. All this with the goal of returning to Spain as a researcher, which wasn’t even guaranteed. In my case, a few months ago, I managed to secure a postdoctoral grant to develop a research project for four years in Zaragoza, so it has been worth it. Specifically, I have returned to INMA to join the group led by Jesús Santamaría (who was also my thesis supervisor), one of the top scientists in Aragon. He has been involved and supported me throughout my journey as a researcher, even while I was abroad, and he advocated for my return to INMA.”

What advice would you give to young women who are considering pursuing a career in science?

“Firstly, if you’re considering it, I believe that research, like other professions or activities, often reveals its fascination only once you experience it from within. Additionally, it’s a profession that greatly nurtures the mind, fills you with stimuli… and it’s very enriching to formulate a hypothesis and be able to test it in the laboratory. I think it’s something rewarding not only professionally but also personally. In addition, it is a profession that allows you to travel to other countries, get to know other cultures, people who started as colleagues and then became friends. On the other hand, all the teamwork it requires is very satisfying. The individual work you do in the laboratory is later contrasted with others. And yes, it is true that there are bad days when things don’t go your way, but when something works out, it more than makes up for it.”

This is great timing for my next question. Have you had any ‘Eureka’ moments? What do you consider your greatest achievement, or something you feel particularly proud of?

“In 2019, there was a moment when there was a cocktail of people who were working exceptionally well and enthusiastically, of the results we were obtaining, and of the project… All of this allowed us to publish my first paper in Nature, which was highly cited afterwards. This was a really cool moment for me.”

Your very own first-author scientific publication… in Nature. And you were still doing your thesis!

“Yes, I was still working on my thesis. But of course, this achievement is not mine alone. It’s very much intertwined with all the teamwork behind it. It’s a publication that goes hand in hand with projects that Jesús Santamaría had at that time, which allowed us to test all the ideas we had. And of course, thanks to the work of many people, like Santamaría himself, Víctor Sebastián, Pilar Martín, and international collaborators we had in Edinburgh… In short, it was a cocktail that allowed us to do something that didn’t exist in the field. No one had tried vesicles with this type of nanoparticles to make catalysts before! It was a group effort, and very satisfying for all of us.”

If someone in your family, who is not a researcher, asked you about your publication in Nature, how would you explain it to them?

“Well, from a scientific point of view, we managed, for the first time, to encapsulate palladium nanosheets in lung cancer exosomes. These nanosheets are harmless to our body, but they can catalyze a reaction that halts the growth of cancer cells.”

And, as you well said, it was a group effort. What was your contribution to that publication?

“What I did was isolate the vesicles and develop a system to produce the nanosheets inside the vesicles without altering their properties. The thing is, up until that point, when attempts were made to attach these nanosheets to the vesicles, the vesicles ceased to be selective to the cancer they were targeted to. This was because the methods used were too aggressive, causing significant damage to the vesicles. What we did was to develop a very gentle method to achieve high encapsulation efficiency and maintain their ability to selectively reach the tumor. On the other hand, our collaborators in Edinburgh studied all the catalysis and reaction dynamics. So, when we administer a systemic prodrug, it’s harmless throughout the body. But as soon as it reaches the tissue where the cancer is located, this prodrug is catalyzed by the nanosheets into its toxic derivative, acting only on the tumor cells.”

That’s brilliant. Plus, you won’t have the biocompatibility issues seen in other drugs.

“Exactly, because the exosomes you use are naturally produced by the cells themselves. That’s the difference compared to other forms of encapsulation. We only tested it at the in vitro level with cells. But imagine being able to use the patient’s own exosomes to encapsulate the nanosheets. This is a starting point to explore this novel therapy further.”

And indeed, it ended up being published in Nature.

(laughs) “Yes, when such a crazy and bold idea gives you such a good result, it kind of gives you the motivation you need to keep going. And that curiosity we were talking about earlier, which I believe every scientist has, produces a very satisfying and inspiring feeling.”

What changes would you like to see in the scientific world to promote gender equality?

“I believe that calls and projects are being adapted more and more to consider maternity leave periods, etc. This allows individuals of all genders to compete on equal terms. However, it’s true that in higher-level positions, certain roles are still more commonly occupied by men. Although, it’s also true that there are more and more female principal investigators (PIs) leading research groups. I think in the future, we’ll see more and more women leading research groups as PIs.”

How do you think we can encourage more women and girls to participate in science?

“There are many science outreach activities highlighting the role of women in science or showcasing prominent female scientists. Activities like this one, promoted by CIBER-BBN, or by other institutions, are important. In my own Institute (INMA), numerous such activities are conducted, which are part of the objectives included in its Strategic Plan. From the scientific community, we are very interested in promoting interest in science, communicating the importance of scientific advances in different research areas, and conveying the daily work carried out at a prestigious research center. At my institute, we strive to make women and girls visible, inspire them, and promote their participation in science. This includes talks, exhibitions, roundtable discussions, competitions, scavenger hunts, activities in pubs, and a series of scientific talks aimed at schools, as well as in-person workshops.

I don’t think we’re doing it wrong. What is more, I think since COVID people have become more aware of the importance of scientific development. A few years ago, few people knew what a PCR was or the effort behind vaccine development. I believe it is important that society as a whole understands what these careers entail.”

That’s all. Thank you very much, María. It’s been very interesting.

“I’m glad!” (laughs)

This is part of a series of interviews to several female researchers within the context of International Day of Women and Girls in Science 2024 and Woman’s Day 2024. For more interviews, visit our news section here.

Additional information:

The goal of NANBIOSIS is to provide comprehensive and integrated advanced solutions for companies and research institutions in biomedical applications. All of this is done through a single-entry point, involving the design and production of biomaterials, nanomaterials, and their nanoconjugates. This includes their characterization from physical-chemical, functional, toxicological, and biological perspectives (preclinical validation).

In order to access our biomedical Solutions, apply here.

NANBIOSIS has worked with pharmaceutical companies of all sizes in the areas of drug delivery, biomaterials and regenerative medicine. Here are a few of them:

Women in NANBIOSIS part 3: Professor Fany Peña, her insights in research, parenthood, and persistence

Prof. Peña gives us her insightful point of view in overcoming challenges, embracing passion, and cultivating collaborative success towards career estabilization.

February 2024, Unizar/CIBER-BBN, Zaragoza (Spain)

The echo of our footsteps returns from the high ceilings filled with electrical conduits and gas pipes. An alarm sounds in the distance, while the warmth of the Zen Garden located in the center of the R&D Building reminds us once again that peace and progress will never be at odds.

We continue forward across the maroon floor, towards one of the access gates that separate each wing of the building. After crossing it, and almost without warning, the echo disappears with the slam of the heavy security door behind us. Now, the noise of the machines muffles our voices and footsteps as we walk through one of the many laboratories of the building. The numerous panels and posters, along with the bustling activity, make it clear that this is a place where science is the undisputed protagonist.

With a strangely welcoming feeling, we enter the spacious laboratory of Professor Estefanía Peña. The light in the room is bright, neutral, and aseptic like the complex machines that adorn it. High-precision devices, some venerable with a history of witnessing scientific breakthroughs, and others, the product of cutting-edge engineering, now contributing to new frontiers.

Two people await us in the room: a young technician, quiet and discreet, and his boss, a woman who, despite, or perhaps as a consequence of her undeniably established scientific career, radiates youthfulness, energy, and determination. Both kindly welcome us to their realm, where they rule over the complex machines. The woman quickly grabs the reins of the conversation, filling the room with her overwhelming, yet approachable personality.

Prof. Peña introduces herself: “Fany, just Fany is fine. That’s how everyone calls me.”

The interview begins.

Alright, Fany, tell us a little about yourself and your research group.

“My group focuses on computational modeling of the human body and pathologies. We also design implants and devices to correct pathologies. We work on real-time simulation and Artificial Intelligence.”

What motivated you to choose a career in research?

“Since I was very young, I’ve loved mathematics, physics, experimenting, asking questions like ‘why does the apple fall?’, and also because of the influence of my family.”

Could you share with us a bit about your research area and the projects you’re currently working on?

“My group is quite large and has three main lines of research: artificial intelligence applied to biological engineering, prosthetic design, lenses, muscle fatigue, and, in the case of those closest to me and Dr. Martínez Barca, the mathematical study of cardiovascular pathologies: myocardial infarction, how these lesions affect the heart, atheroma plaque, and devices to try to correct vessel obstruction. Recently, we’ve been working on modeling aneurysms in collaboration with groups from Val d’Hebron Hospital.”

Have you had any Eureka moments in your career? What do you consider to be your greatest achievement or contribution in your field at a professional or personal level?

“Probably my first doctoral thesis. Feeling capable of teaching and mentoring someone was a significant milestone for me. The topic was about carotid stents.”

What have been the biggest challenges you’ve faced as a woman in your research field?

“The biggest challenge has been balancing personal life, especially family life, with work. Especially when you’re young. I’m someone who, when I dedicate time to something, I dedicate it in full. Moreover, the moment when you have to dedicate much more time to a research career starts right after you finish your doctoral thesis until you reach professional stabilization. And that’s usually the period when you start a family. That’s a key moment and the greatest difficulty that, I believe, 99.9% of female researchers face.”

How do you think these barriers can be overcome?

“To be honest, I acknowledge that the role of a mother is almost irreplaceable. However, I believe that society is still not prepared to understand that women, besides being mothers, also want to do other things. It’s not just a problem of task distribution; I think nowadays roles in motherhood and fatherhood are quite shared, especially among young people. I believe it’s more of a social issue, meaning that even in terms of state aid aimed at encouraging motherhood, it’s scarce. Imagine, in other countries it’s inconceivable not to have a daycare or a similar service at the workplace. I think the role of a mother is very important, but…”

…having a daycare at work helps, right?

“It helps quite a bit, yes.”

“The most important thing in your professional career is to dedicate yourself to something you love (…) that’s incredibly important from a professional point of view.”

—Prof. Estefanía Peña, Scientific Coordinator of Unit 13.

What advice would you give to young women considering pursuing a career in science?

“Go for it! The most important thing in your professional career is to dedicate yourself to something you love. I mean, family and your personal life bring the greatest happiness, yes, but I know many people who work in something they don’t like, either because they haven’t found work anywhere else or because they opted to study something easy back then, even if they didn’t like it that much… I believe that working in something you love allows you to do things much better, and that’s incredibly important from a professional point of view. Study and do what you love, and if you love science… go for it!”

And what about all those girls who doubt?

“Yes… the truth is, from the talks I’ve given at schools, the response from girls often is ‘Phew!’ And usually, the female ratios, in my case as an engineering professor, are very, very low. But success rates, the highest grades… there’s no distinction there. It’s a 50/50. That means there’s no added difficulty, beyond the intrinsic difficulty of a science career, which both men and women will feel equally. Probably women will have more advantage since, for whatever reason, we tend to be able to focus more and be, as we use to say in Aragon, ‘more stubborn’. It doesn’t really matter much if subjects are more difficult because when you really like what you do, you don’t mind dedicating more time to it.”

What support have you received throughout your career that has been particularly useful?

“My colleagues, without a doubt. I’ve had people I’ve worked with and continue to work with since I started my thesis. There are people I’m still working with whom I started working with 25 years ago. And I have the utmost confidence that if I’m on maternity leave, nothing will go wrong. Or that if one of my colleagues fails, the rest of us will always be there. That’s extremely important. I don’t think it’s necessary to mention specific names. Science is very collaborative, whether from a teaching or research perspective. I always say ‘tanto monta, monta tanto’.” [Interviewer’s Note: a historical idiomatic expression when both king and queen held equal authority and power in the newly unified kingdom of Aragón].

Very Aragonese phares as well.

“Yes, very Aragonese.”

Thank you very much for your time, Fany.

“Thank you very much, Gabriel.”

This is part of a series of interviews to several female researchers within the context of International Day of Women and Girls in Science 2024 and Woman’s Day 2024. For more interviews, visit our news section here.

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