JUMISC

Agreement signed with Spanish Government for the allocation of FEDER funds for Nanbiosis ICTS

In the framework of the FEDER Program in ICTS 2014-2020, a projects related to the ICTS NANBIOSIS has been selected by the Ministry of Science, Innovation and Universities for co-financing with FEDER funds of the European Regional Development Funds program.

An agreement has been signed between Ministry of Science, Innovation and CCMIJU, institution that houses NANBIOSIS U14, U19, U21, U22, U23, U24 for the co-financing of the Project ICTS-2019-14-46: “ACTUALIZACIÓN DE LAS INFRAESTRUCTURAS E IMPLEMENTACIÓN DE UN SISTEMA DE CONTROL DOCUMENTAL Y DE GESTIÓN LIMS PARA POTENCIAR LAS CAPACIDADES DE LAS UNIDADES DE LA ICTS DISTRIBUIDA NANBIOSIS (AILIMS-NANBIOSIS)”

The total budget of the project amounts to € 597.000, with 80% financing with FEDER Funds.

CCMIU is processing the necessary contracting procedures for the execution of this project.

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Looking for volunteers to validate an online learning of minimally invasive surgery (MIS) platform in the framework of EASIER project

The EASIER Project “Technology-enhanced learning of surgical and interventional technical and non-technical skills”, co-founded by the Erasmus + Program of the UE, introduces an innovative paradigm for online learning of minimally invasive surgery (MIS).

EASIER introduces an innovative paradigm for online learning of minimally invasive surgery (MIS) and interventional skills. CCMIJU, partner of NANBIOSIS, is part on the poroject and provides the tools to create pedagogically curated learning courses where students can train both their technical and nontechnical skills. The platform will provide seamless integration of third-party assets (box trainers, virtual reality simulators) that can be used to program simulator tasks as part of specific courses. Course assessment is broken down by the different technical and nontechnical skills, providing a comprehensive record of the resident’s progress to mastery.

NANBIOSIS units at CCMIJU are involved in the project, especially NANBIOSIS U21. Experimental operating rooms, led by Dr. Francisco M. Sánchez Margallo

For more information on project EASIER please visit easier-project.eu, download our cartel or flyer.

Once you complete registration, you are welcome to join us at our kick-off webinar on the 17th December 2020 from 16:00-16:45 CET, where we will present:

The EASIER project goals and mission
The EASIER platform
The validation trials

All volunteers completing the validation will gain exclusive early information before public release and a 1-year free subscription to the EASIER platform.

Enrolment: here

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NANBIOSIS-ICTS AT CASEIB 2020

The XXXVII Annual Congress of the Spanish Society of Biomedical Engineering (CASEIB) is taking place between November 25 and 27. This new edition of CASEIB, in virtual format is organized by the CIBER-BBN group of Biomedical Engineering at Valladolid Universitiy, led by Prof. Roberto Sánchez Hornero.

Prof. Laura Lechuga, Scientific Director of NANBIOSIS U4 Biodeposition and Biodetection Unit, member of the advisoty committee of scientific experts (Multidisciplinary Working Group) to the Ministry of Science and Innovation in COVID-19 and coordinator of the European project CONVAT shall participate in the Roundtable I: Biomedical Engineering and COVID-19 November 26, 12:00 h

Researchers of BSICoS Group from CIBER-BBN and I3A-UZ, running NANBIOSIS U27 High Performance Computing, led by Prof. Pablo Laguna, will participate defending their last works:

“Delay between QT and RR in stress test records as an indicator of the heterogeneity of ventricular repolarization”. Cristina Pérez, Esther Pueyo, Juan Pablo Martínez, Jari Viik, Pablo Laguna.
“Prediction of sudden death in patients with chronic heart failure by studying the periodic dynamics of repolarization”. Saúl Palacios, Iwona Cygankiewicz, Antoni Bayés-de-Luna, Juan Pablo Martínez, Esther Pueyo.
“Electrodermal response analysis for the identification of patients with depression”. Marta Martínez, Jesús Lázaro, Spyridon Kontaxis, Pablo Laguna, Eduardo Gil, María Luisa Bernal Ruíz, Sara Siddi, Concepción de la Cámara, Jordi Aguiló, Esther García, Josep María Haro, Raquel Bailón.
“In silico characterization of the duration of repolarization and its variability in Type 1 Long QT syndrome under β adrenergic stimulation”. David Adolfo Sampedro-Puente, Fabien Raphel, Jesús Fernández-Bes, Pablo Laguna, Damiano Lombardi, Esther Pueyo
“Monitoring of Blood Potassium Concentration in dialysis through changes in the multi-lead morphology of the T wave: Comparison between using the transformation in Periodic and Principal Components”. Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Dina Ferreira, Alba Martin, Esther Pueyo, Pablo Laguna, Juan Pablo Martínez, Julia Ramírez.

Further information on BSICoS website

On the other hand researcher of NANBIOSIS at JUMISC will present:

“Study of the influence of the diameter and temperature of the nozzle on the thickness of the filament for bioprinting“. Enrique Mancha, Juan Carlos Gómez Blanco, Alfonso Carlos Marcos Romero, Manuel Matamoros Pacheco, Francisco Miguel Sánchez Margallo, José Blas Pagador Carrasco.
Influence of voluntary contractions on the basal sEMG activity of the pelvic floor muscles. M. Albaladejo-Belmonte, M. Tarazona, F.J. Nohales, J. Alberola-Rubio, J. Garcia-Casado
3D Printing Mold Making: Soluble Male Viability for Hollow Artificial Organs Juan Carlos Gómez Blanco, José Blas Pagador Carrasco, Antonio Jesús Rodríguez Fuentes, Alfonso González González, Mara Olivares Marín, Jesús Usón Gargallo, Francisco Miguel Sánchez Margallo

Further information on JUMISC website

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NANBIOSIS in the new poster of ICTS map published by Spanish Goverment.

ICTS underpins the Spanish reputation for research excellence.

In the picture: the new poster of the ICTS map in which NANBIOSIS facilities have been highlighed with a red square

The term Unique Scientific and Technical Infrastructure (ICTS) refers to facilities, resources, or services for the development of top-quality cutting-edge research, as well as the communication, exchange, and preservation of knowledge, the transfer of technology, and promotion of innovation. They are unique or exceptional in their fields, with a high cost of investment, maintenance, and operation, and are of a strategic importance that justifies their availability to all actors in the field of R&D&I. The ICTS share three fundamental characteristics; they are infrastructures with public ownership, unique and open to competitive access.

ICTS offer an opening capacity percentage of their essential services under ‘Competitive Open Access’ for the use by national and international public and private sector researchers, with the support of technical and administrative personnel of the ICTS. Infrastructures access is ruled by a public “Access Protocol” that describes the procedure and criteria for access to the infrastructure. The main features of ‘Competitive Open Access’ are that R + D + i quality of activities developed at the infrastructure should be proven and that requests for access should be prioritized on the basis of objective criteria.

The dissemination of ICTS and their capabilities is essential to provide Spanish and international researchers with access to a large base of quality services and facilities, a basic requirement for the development of excellent science.

The new posster pushised by the General Subdirectorate of Large
Scientific-Technical Facilities of the of the Sapanish Ministry of Science and Research Innovation helps to disseminate and understand the map of ICTS wich are located throughout the country

NANBIOSIS, is one of the five ICTS in the field of Health Sciences and Biotechnology

Further informations: MICINN

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III Course on Introduction to research and laboratory techniques in Biosciences

CCMIJU has organised the III Course on Introduction to research and laboratory techniques in Biosciences, which wil take place at JUMISC on December, 18th, 2020 under the Direction of Esther López Nieto and Javier García Casado, Scientific Director of NANBIOSIS U14 Cell Therapy. Other researchers of NANBIOSIS Units offer their expertise as Beatriz Moreno Lobato, Scientific Diector NANBIOSIS U19 and Luis Dávila Gómez, Scientific Director of NANBIOSIS U22

The course contents are distributed in the following blocks:

Block I. Knowledge pills for research – Theory
Research career and aid for hiring (Dr JG Casado). 30 min
Communication of research results (Dra. E López). 30 min
Introduction to bibliographic resources. (Dra. R Blázquez). 30 min
Research Projects: preparation and evaluation (Dr JG Casado). 30 min
Protection of research results. Intellectual and industrial property. (JL Añover). 30 min

Block II. Knowledge pills for research – exercises / case studies
Practical case 1: Bibliographic search and Commentary and assessment of different scientific communications: 1.5h
Block III. RNA and DNA: gene expression and genetic studies in reproduction
Introduction to the analysis of gene expression using qPCR (F Marinaro and E López). 1h 30min
Pre-implantation genetic diagnosis in assisted reproduction clinics (E Delgado). 1 hour

Block IV. Proteins and proteome: protein expression studies and massive proteomics analysis / identification
Protein expression study I: Introduction to immunoprecipitation and western blotting techniques (E López). 1 hour
Introduction to the study of proteins II: Generalities and principles of proteomics in cardiovascular research (I Jorge). 1h 30min

Block V. Cell cultures: stem cell cultures and production for clinical uses
Cell cultures I: Isolation of adult stem cells and characterization (R Blázquez). 1 hour
Cell cultures II: Production, commercialization and clinical uses of cell therapy (O delaRosa). 1h 30min

Block VI. Miscelanea: Histology, clinical analysis, 3D bioprinting and animal experimentation
Basic fixation, inclusion and staining techniques for histology (A Usón). 1 hour
Basic techniques for determining blood parameters: Biochemistry and hematology (B Moreno). 1 hour
Technology and materials in the 3D bioprinting laboratory (JC Gómez). 1 hour
Minimally invasive experimental procedures in laboratory animals (L Dávila). 1 hour

Block VII: Laboratory techniques in biosciences – exercises / practical cases
Practical case-example 2: Analysis of qPCR results. 1,5h

Further information: Programm and inscriptions

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XIV COURSE OF LAPAROSCOPIC SURGERY OF COLON

CCMIJU has organised the XIV Course of Laparoscopic Surgery of Colon, which wil take place at JUMISC from 14 December to 16 December 2020 under the Direction Francisco Miguel Sánchez Margallo (Deputy Scientific Director of NANBIOSIS)

Two of the main lines in the activity of the Minimally Invasive Surgery Centre (CCMIJU) are the Innovation and medical training in collaboration with hospitals and companies of the medical sector, with the aim to improve the quality of healthcare delivered to patients, by providing
surgeons and other health professionals with innovative solutions and
training. The CCMIJU is part of the Singular Scientific-Technical Facility
(ICTS) NANBIOSIS, featuring state-of-the-art technology to be
used during the training courses.

Frurther information: Programm and inscriptions

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Combination of stem cell therapy and laparoscopy for the treatment of congenital hernia

Researchers of CCMIJU and NANBIOSIS Unit 14 Cell Therapy, led by Javier García Casado, have recently published a study with the purpose to combine stem cell therapy and laparoscopy for the treatment of congenital hernia in a swine animal model proposing an easy and feasible method to combine stem cell therapy and minimally invasive surgical techniques for hernia repair, the first preclinical study evaluating the use of stem cell therapy in the field of abdominal hernias in a clinically relevant swine model with congenital hernia

Surgical procedures and imaging diagnoses were performed at the ICTS NANBIOSIS Unit 21 Experimental operating rooms, led by Francisco M. Sánchez Margallo

“We developed an experimental approach to test whether the use of stem cells for abdominal hernia treatment is viable in a clinically relevant animal model. To the best of our knowledge, this is the first preclinical study where pigs with congenital abdominal hernias were treated with surgical meshes seeded with adult stem cells. Additionally, the surgical approach was performed with minimally invasive procedures to avoid complications related to open surgery. An exhaustive follow-up was performed at different time points using different evaluation methods: ultrasonography, gene expression analysis, complete histological evaluation, and cellular characterization by flow cytometry of infiltrated leukocytes.”

Article of reference:

Laparoscopy for the Treatment of Congenital Hernia: Use of Surgical Meshes and Mesenchymal Stem Cells in a Clinically Relevant Animal. Federica Marinaro, Javier G. Casado, Rebeca Blázquez, Mauricio Veloso Brun, Ricardo Marcos, Marta Santos, Francisco Javier Duque, Esther López, Verónica Álvarez, Alejandra Usón and Francisco Miguel Sánchez-Margallo. ModelFront. Pharmacol., 25 September 2020 https://doi.org/10.3389/fphar.2020.01332

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New project to alleviate the effects of Covid will be developed by JUMISC, partner of NANBIOSIS

The Jesús Usón Minimally Invasive Surgery Center (JUMISC), partner of NANBIOSIS, will develop an R&D project aimed at alleviating the effects of the health and social crisis of COVID-19, thanks to a collaboration agreement with Banco Santander.

The project “Analysis of ligands for SARS-CoV-2 in lymphocyte subpopulations with application for disease staging and patient stratification“, will be developed for a year with the collaboration of researchers from from the San Pedro de Alcántara Hospital in Cáceres, the University of Extremadura, the Reina Sofía Hospital and Mount Sinai in New York.

This research initiative aims to provide a reliable prediction of the development of the disease through the study of certain molecules related to the mechanisms of entry of the virus and how they are altered depending on the age and immune status of the individual. The result of the characterization of SARS-CoV-2 receptors and their correlation with the degree of differentiation of lymphocytes of patients could allow, by means of cytometric analysis, the stratification of patients.The project includes three phases: the first will define a panel of antibodies to identify, by cytometry, those subcellular populations with high levels of expression of ligands for the virus; in the second, the panel of markers already defined will be analyzed and the third will allow to establish groups of patients according to the stage of the disease and predict the evolution of those diagnosed.

For further information, click here

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The Immunomodulatory Signature of Extracellular Vesicles From Cardiosphere-Derived Cells: A Proteomic and miRNA Profiling

Researcher of CCMIJU published an article in the scientific journal FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY with the participation of NANBIOSIS Unit 14 of Cell Stem Cell
Therapy where culture and in vitro studies were
performed,

The researchers have shown that the regenerative potential and immunomodulatory capacity of cardiosphere-derived cells (CDCs) is mediated by paracrine mechanisms. In this process, extracellular vesicles derived from CDCs (EV-CDCs) are key mediators of their therapeutic effect. Considering the future applicability of these vesicles in human diseases, an accurate preclinical-to-clinical translation is needed, as well as an exhaustive molecular characterization of animal-derived therapeutic products. Based on that, the main goal of this study was to perform a comprehensive characterization of proteins and miRNAs in extracellular vesicles from porcine CDCs as a clinically relevant animal model.

The analysis was performed by identification and quantification of proteins and miRNA expression profiles. The results revealed the presence of clusters of immune-related and cardiac-related molecular biomarkers in EV-CDCs. Additionally, considering that priming stem cells with inflammatory stimuli may increase the therapeutic potential of released vesicles, here we studied the dynamic changes that occur in the extracellular vesicles from IFN gamma-primed CDCs. These analyses detected statistically significant changes in several miRNAs and proteins. Notably, the increase in interleukin 6 (IL6) protein, as well as the increase in mir-125b (that targets IL6 receptor) was especially relevant. These results suggest a potential involvement of EV-CDCs in the regulation of the IL6/IL6R axis, with implications in inflammatory-mediated diseases.

Article of reference: DOI: 10.3389/fcell.2020.00321

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Workshops on Robotic Surgery with experimental models at CCMIJU

This year, CCMIJU, partner of NANBIOSIS, at Cáceres, has organised some new hands-on and customised workshops with robotic technology, expected for 2020 last term.

Specifically CCMIJU is organising, in collaboration with the Enterprise ABEX-Excelencia Robótica SL, some workshops on Robotic Surgery (da Vinci Xi) using experimental models. They are addressed to health professionals from several specialties (urology, gynaecology, general surgery and thoracic surgery) interested in practising with this technology.

The workshops will count on a clinical specialist from ABEX, who will explain the technical features of the robotic equipment, the associated technologies and the virtual simulator for exercises. Subsequently the health professionals, monitored by a tutor-specialist, will be able to practice a surgical approach on the virtual simulator and in vivo, on experimental models.

The mentioned workshops will be developed in a full day, morning- afternoon, in two sessions: virtual simulation an in vivo model. Both of them will be customised and will count on a tutor for surgical training in experimental models.

The focus is to improve the patients’ health care, training surgeons and health professionals in innovative solutions.

For further info, please e-mail idoiadiaz@ccmijesususon.com

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