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Equipments

Equipments

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U9-E08. Portable Tándem NanoScan SMPS Nanoparticle Sizer 3910 and Optical Particle Sizer (OPS) 3330

Equipment funded by European Union (NextGeneratioEU) -Plan de Transfomación y Resilencia

Portable Particle sizers acquired for Unit 9 in NANBIOSIS through Next Generation Funding.

Description: NanoScan SMPS™ Nanoparticle Sizer delivers a TSI Scanning Mobility Particle Sizer (SMPS™) spectrometer in a portable package that is about the size of a basketball. Easy to use, lightweight and battery-powered, the NanoScan SMPS™ spectrometer enables investigators to collect valuable nanoparticle size data. The NanoScan SMPS™ Nanoparticle Sizer spectrometer is suitable for a variety of applications, such as a multitude of mobile studies, workplace exposure monitoring, point source identification, and student lab education. Derived from TSI core technologies, the NanoScan SMPS spectrometer is an innovative, cost effective solution for real-time nanoparticle size measurements.

Technical Specifications: Weighing less than 20 pounds (including two hot-swappable batteries), the NanoScan SMPS™ Nanoparticle Sizer 3910 measures nanoparticle size distributions from 10 to 420 nm in one minute. Its internal Condensation Particle Counter (CPC) uses isopropyl alcohol as a working fluid, so the NanoScan is suitable for use in a variety of sensitive environments. Single particle mode allows the user to monitor particle concentrations of a single, user-set particle size. Data logging is built in to the instrument, so measurements may be made without the use of a laptop.

As a package, i.e. the model 3910 combined with the Optical Particle Sizer (OPS) 3330 enables users to measure three orders of size magnitude from 10 nm to 10 µm. These instruments are affordable, portable, and provide real-time data that can be merged with the multi-instrument manager (MIM) software. Used already for cabin measurements in cars and airplanes, the sky is literally the limit when it comes to new applications. Quantification thresholds reach to maximum concentrations of up to 150.000 particles per cm3.

Applications: General applied research; Indoor/outdoor air quality investigations; Nanotechnology/nanoparticle applications; Combustion/emission research; Mobile studies; Health effects/inhalation toxicology; Occupational hygiene/workplace exposure monitoring; Point source identification.

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U9-E08. Laser Pyrolysis improvement

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U16-E07. Equipment for microbiology tests on materials. OUTSTANDING

Description: It is the set of precise elements to carry out microbiological tests with materials. Includes laminar flow adhesion chambers, Robbin devices, shaker and drip bioreactors, fluorescence microscopes, plate readers, ovens, autoclaves, etc.

Technical specifications: Allows quantifications on different types of systems. Depending on the specific conditions, it is possible to evaluate behavior in extensive solid materials or in suspension.

Applications: The services that can be provided with this equipment are:
Evaluation of the adhesion capacities and formation of biolayers of microorganisms on materials. Evaluation of bactericidal and/or bacteriostatic responses of materials.

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U13-E04. Micro-scale tension-compression test system CellScale.

Test system for small samples including:

  • Main equipment (Micro-scale tension-compression test system)
  • Tangential test module (Shear Axis add-on for MicroTester system)

Description: Enhanced for smaller samples, the MicroTester offers improved force resolution, streamlined test setups, and exceptional visual feedback. It’s ideal for a wide range of applications, from tiny tissue samples to hydrogel microspheres, cell spheroids, and engineered microtissues.

Technical specifications: Piezo-electric actuators with 0.1µm resolution Optional second axis imaging Force resolution down to 10nN High resolution CCD imaging Integrated temperature-controlled media bath Fully featured user interface software for simple, cyclic, relaxation, and multi-modal testing with real-time feedback

Aplications: Compression, tension, bending, indentation and shear testing

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U30-E05. Small equipment for protein detection/quantification

Small equipment for protein detection/quantification

Description: Under this concept, the Unit has the following instruments:

  1. MagPix reader (Luminex), for the readout of magnetic bead–based immunoassays designed on xMAP beads. Allows the quantification of up to 50 analytes per sample.
  2. DIGE Imager (GE), for the digitalization of difference in-gel electrophoresis (DIGE) gels or stained with fluorescence (SYPRO, etc.).
  3. Amersham Imager 600 (GE), for the detection and digitalization of fluorescence or quimioluminiscence signals in gels or membranes.

Applications: Detection and/or quantification of proteins.

E05 MagPix reader
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U30-E04. Small equipment for protein separation

Small equipment for protein separation

Description: Under this concept, the Unit has the following instruments:

  1. High-performance liquid chromatography (HPLC) system with UV detector (Agilent 1200 Series), for the chromatographic separation of proteins by reversed phase, ion exange, gel filtration or affinity.
  2. Two IPGPhor systems (GE Healthcare), for the separation of proteins by isoelectric focusing.
  3. Protein electrophoresis units: MiniProtean (Bio-Rad), SE600 Ruby (GE Healthcare) y Ettan™ DALTsix (GE Healthcare), for running gels up to 24×26 cm to separate proteins according to their size.
  4. Microfraction collector and spotter SunCollect (SunChrom), to collect fractions coming out of the nLC and deposit themo onto MALDI plates for mass spectrometry. 

Applications: Separation of proteins in liquid or gel supports, according to a wide variety of physicochemical properties.

E04 SunChrom spotter
E04 HPLC 1200 series
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U30-E03. MALDI-TOF/TOF System

MALDI-TOF/TOF System

Description: 4800 Proteomics Analyzer (Sciex)

Technical specifications: Mass spectrometer equipped with a matrix-assisted laser desorption/ionization (MALDI) source, using a Nd:YAG 200-Hz laser, and two time-of-flight mass analyzers in tandem with a high-energy collision-induced disociation (CID) chamber for ion fragmentation. It has a variable ion path length to accomodate MS linear, MS reflector and MS/MS acquisition modes.

Applications: Determination of molecular masses of peptides, proteins and other biomolecules. Protein identification by peptide fingerprint or peptide fragmentation. Shotgun quantitative proteomics analyses by isotopic labeling and LC-MALDI workflows.

E03 MALDI-TOF/TOF System
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U30-E02. QTRAP LC-MS/MS System

QTRAP LC-MS/MS System

Description: Tempo™ nanoLC-2D liquid chromatography system coupled to QTRAP5500 mass spectrometer (Sciex).

Technical specifications: The QTRAP® 5500 LC-MS/MS system (Sciex) is a triple quadrupole combined with a trap-type accelerator. It has two electrospray ionization sources (nano source and turbo source).

Applications: Determination of molecular masses of peptides, proteins and other biomolecules. Absolute quantification of proteins using isotope-labeled standards. Targeted quantitative proteomics analyses by multiple reaction monitoring (MRM).

U30 E02 QTRAP LC-MS/MS System
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U30-E01. TIMS TOF Pro LC-MS/MS System

TIMS TOF Pro LC-MS/MS System

Description: Liquid nanochromatography system coupled to high resolution mass spectrometry with ion mobility (Bruker).

Technical specifications: The system consists of a nanoElute® chromatograph, which works at gradients between 50-2000 nL/min and is coupled to a TimsTOF mass spectrometer (Bruker) with an electrospray source. This spectrometer has two analyzers in hybrid configuration quadrupole and time of flight. It features a TIMS ion mobility trap that adds a fourth dimension of separation, as well as PASEF (Parallel Accumulation Serial Fragmentation) technology, which enables sequencing speeds of over 100 Hz, providing extremely high throughput and sensitivity.

Applications: Determination of molecular masses of peptides, proteins and other biomolecules. Protein identification by peptide fragmentation. Shotgun quantitative proteomics analyses by isotopic labeling (SILAC, iTRAQ, TMT…) or label-free (LFQ). Targeted quantitative proteomics analyses by PRM.

E01 TimsTOF Pro LC-MS/MS system (Bruker)
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U26-E07. MRS*DRYMAG3017-Flexiscan

Equipment Features:

Description: 3T preclinical imaging equipment with PET ClipOn attached.

Technical specifications: Imaging equipment with superconducting magnet, capable of varying the angle from 0 to 90º, without cryogenics of 3 Teslas; mouth diameter of 170mm; 600 mT/m gradients with 5% linearity; 30 mm DSV for Homogeneity and 0.05 ppm/hour for stability; 350 Kg of total weight.

Applications:

Acquisition and viewing of in vivo images of mice and rats as well as other beings or materials of similar size.

  • Qualitative and quantitative studies (relaxation times T1 and T2 and even making maps) at the brain level and other organs.
  • Cardiological sequences: diffusion, determination of blood volume…
    Anatomical and functional studies of different organs (for example: renal, abdominal, liver…).
  • Bone-level imaging, distinguish between bone material from soft tissue.
    Fat suppression techniques.
  • Oncological studies to detect and locate tumors and volume calculation.
  • Carry out studies on fruits and vegetables (grapes, kiwi, tomato, seeds…).
  • Perform studies with/without contrast (Gadolinium) and see the differences between the 2 images.
  • Thanks to the possibility of rotating the equipment in a vertical position, images of plants can be obtained (because by their nature, they have to be in a vertical orientation, such as a stem).
  • Ex-vivo studies can also be carried out vertically and in this way we maintain the integrity of the organ (eg heart).
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