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Biomaterials & nanomaterials production - Equipment

Biomaterials & nanomaterials production – Equipment

U8-E06. Chemical banks for micro/nanotechnologies

Chemical banks for micro/nanotechnologies.

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U8-E05. CVD nitride and oxide passivation equipment

CVD nitride and oxide passivation equipment.

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U8-E04. Optical photolithography equipment

Optical photolithography equipment.

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U8-E03. Platinum and gold deposition equipment

Platinum and gold deposition equipment.

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U8-E02. Thermal oxidation process equipment.

Thermal oxidation process equipment.

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U6-E11. Turbiscan Lab

Turbiscan Lab

Description: Turbiscan is used to detect at an early stage all kinds of destabilisation such as coalescence, flocculation, creaming, sedimentation, etc… Various products such as emulsions, suspensions or foams can be studied from low to high concentrations without any sample preparation or dilution. Stability kinetics and index are measured for an efficient sample analysis and comparison.

Applications: Stability studies

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U7-E15.

Contact Angle (OCA15 plus).

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U6-E03. Four Glove Dispensing isolator for expermiments with highly active and cytotoxic compounds

Four Glove Dispensing isolator for expermiments with highly active and cytotoxic compounds.

Description: The four-glove isolator is a safe chamber, with controlled environment for the weighing and handling of potent drug compounds.

Technical specifications: The Isolator has been designed to offer containment to a working OEL (Occupational Exposure Limit) of less than 0.1Jgrams/m³ time weighted average over an 8hr operational period (TWA).

The Isolator is designed to offer an internal air cleanliness of Class 8 as described in ISO 14644-7 and the test pass criteria is a leakage rate of ≤0.25% vol/hr and is in line with Class 2 classification of ISO 14644-7.

  • Internal Environment: – Main Chamber: -100Pa +/- 10%.
  • Air Changes per hour: Nominal 20 during normal operating conditions giving ISO 8.
  • Glove Breach Velocity: >0.5m/sec.
  • Exhaust System: Max air flow 108m3/hr.
  • Inlet HEPA Filter: H14 Canister (safe-change when changed into Isolator). 99.995% efficient @ 3Jm particle size.
  • Exhaust HEPA Filter: 1st Stage – H14 HEPA & 2nd Stage – H14 HEPA mounted within Push-Push Safe Change housing 99.995% efficient @ 3Jm particle size.

Applications:

Pharmaceutical Manufacturing: In pharmaceutical manufacturing, especially for the production of potent drugs or active pharmaceutical ingredients (APIs), a 4-glove isolator can be used for containment. It helps in preventing cross-contamination and ensures the safety of both the product and the operator.

Biotechnology Research: In research laboratories working with hazardous biological materials such as viruses, bacteria, or genetically modified organisms (GMOs), a 4-glove isolator provides a secure environment for manipulation and experimentation. It minimizes the risk of exposure to harmful agents.

Sterile Compounding: In compounding pharmacies and hospital pharmacies, a 4-glove isolator can be utilized for sterile compounding of medications. It helps in maintaining aseptic conditions, preventing contamination, and ensuring the safety and efficacy of compounded drugs.

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U6-E14. Microcalorimeter for measurements under Isothermal Titration Calorimetry (ITC)

MicroCal VP-ITC – Malvern

Description:

Isothermal titration calorimetry (ITC) measures the binding affinity and thermodynamics between two biomolecules. When substances bond, heat is released or absorbed. Measuring this heat change in an ITC experiment allows precise determination of the binding constants (KD), stoichiometry (n), enthalpy (ΔH) and entropy (ΔS), providing a complete thermodynamic profile of the molecular interaction in a single experiment.
The MicroCal VP-ITC system is a powerful, sensitive and easy-to-use calorimeter that offers the possibility of investigating any biomolecular interaction. This rapid, convenient, label-free, and solution-based technique provides the information needed to characterize the molecular interactions of proteins, antibodies, nucleic acids, and other biomolecules.

Technical specifications:

• Cell type: Non-reactive Hastelloy
• Sample volume 2 mL
• Volume per cell: 1.4 mL
• Volume injected: 0.3 mL
• Mixing speed: user selectable
• Response time: user selectable
• Working temperature: 2º to 80º C

Applications:

• Characterization of molecular interactions of proteins, antibodies, nucleic acids and other biomolecules.
• Kinetic enzyme.
• Evaluation of the effect of molecular structural changes on binding mechanisms.
• Evaluation of biological activity.

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U6-E12. Autotap instrument for packed density measurements of powders

Autotap instrument for packed density measurements of powders.

Descripción: Bulk density and powder packing tests

Each particle of a solid material has effectively the same true density regardless of size or shape, but more or less geometric space is occupied by the material according to the relative particle-particle cohesion and mechanical interference. That is, the apparent bulk densities of powdered, granular or flaked materials are highly dependent on the manner in which the particles are packed together. Furthermore, handling or vibration of particulate material causes the smaller particles to work their way into the spaces between the larger particles. The geometric space occupied by the powder decreases and its density increases; ultimately no further natural particle packing takes place without the addition of pressure and maximum particle packing is achieved. Under controlled conditions of tapping rate, tap force drop and cylinder diameter, this condition of maximum packing efficiency is highly reproducible. Tap density measurement is formalized in a number of international standards to which Autotap conform.

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