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Resolution of the 2nd competitive call of 2023 for access to NANBIOSIS

NANBIOSIS is a Research Infrastructure for Biomedicine made up of the Platforms of the Center for Centro de Ivesntigación Biomedica en Red (CIBER- in the area of Bioengineering, Biomaterials, and Nanomedicine -CIBER-BBN), the Preclinical Infrastructure and the Development of Minimally Invasive Technologies, of the Jesús Usón Minimally Invasive Surgery Center (CCMIJU) and the Nanoimaging unit of the Biomedical Research Institute of Malaga-Nanomedicine Platform (IBIMA-BIONAND Platform).

NANBIOSIS as part of the Spanish Map of ICTS (an acronym for “Scientific and Technical Unique Infrastructures” in Spanish), approved by the Ministry of Science and Innovation, is open to all interested national and international users who may come either from the public or the private sector, and who can apply for access under the “Competitive Open Access” or “Access on Demand” modalities.

The 20% of the NANBIOSIS Units’ capacity is granted on the Competitive Open Access modality and will be prioritized according to scientific and technical quality and singularity of the applictions.

Consult the Resolution and details here

Related News:

2nd Open call 2023 for preferential access to the NANBIOSIS ICTS
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Jesús Santamaría, Scientific Director of NANBIOSIS Unit 9, elected foreign member of the Istituto Lombardo Accademia di Science et Lettere

Jesús Santamaría, Professor of Chemical Engineering at the University of Zaragoza, has been elected a foreign member of the Istituto Lombardo Accademia di Science et Lettere, in its division of Mathematical and Natural Sciences, Chemistry section.

This institution was originally founded by Napoleon Bonaparte in 1797, as the National Institute of the Cisalpine Republic, in charge of collecting discoveries and perfecting the arts and sciences, following the model of the Institut de France. Napoleon himself appointed the first members of the Institute and its first president, Alesssandro Volta, Italian chemist and physicist, famous primarily for the discovery of methane in 1776 and the invention and development of the electric battery in 1799 .

Today the Istituto Lombardo depends on the Italian Ministry of Culture with headquarters in the Brera Palace, and has maintained its founding task of contributing to “issues related to education and public welfare. It currently develops a wide program of activities, including support for research in the fields of action of the institution, numerous events and public conferences, as well as its publications and the management of its famous archives and library.

Among the members who have belonged to the Istituto Lombardo are, in addition to Napoleon himself and Volta, the poet Vincenzo Monti, the writer and politician Alessandro Manzoni, the philosopher Carlo Cattaneo and the cleric Achille Ratti, future Pope Pius XI, as well as several Nobel Prize winners. : Camillo Golgi (Medicine), Giosuè Carducci (Literature), Giulio Natta (Chemistry) and Eugenio Montale (Literature).

Professor Santamaría has a long and profuse career in the academic and scientific field, with 370 published articles, 35 doctoral theses supervised, 26 patents and participation in 18 European projects, including two of the prestigious Advanced Grants from the European Research Council (ERC),. Jesús Santamaría is the Principal Investigator of the NFP (Nanostructured Films and Particles) research group, that belongs to the Aragon Institute of Materials and Nanoscience (INMA), CSIC-UNIZAR joint center, the Aragon Health Research Institute (IIS Aragon), and the Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN). He is also the Scientific Director of NANBIOSIS U9 “Synthesis of Nanoparticles Unit” since its creatrion in 2007 by UNIZAR and CIBER-BBN, recognized by the Spanish Governmen as “Unique Scientific and Technical Infraestructure” (ICTS in Spanish) .

Santamaría has been director of the Samca Chair of Nanotechnology, deputy director of the Unizar Nanoscience Institute of Aragon and editor of the Chemical Engineering Journal. He has carried out postdoctoral research stays at the University of Notre Dame and at the Massachusetts Institute of Technology (MIT), both in the United States.

His current research topics include the development of new methods for the synthesis of nanomaterials, and applications of the synthesized materials in medicine, photo-assisted catalysis, microwave catalysis, molecular recognition sensing, and nanosafety.

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U9-E08. Portable Tándem NanoScan SMPS Nanoparticle Sizer 3910 and Optical Particle Sizer (OPS) 3330

Equipment funded by European Union (NextGeneratioEU) -Plan de Transfomación y Resilencia

Portable Particle sizers acquired for Unit 9 in NANBIOSIS through Next Generation Funding.

Description: NanoScan SMPS™ Nanoparticle Sizer delivers a TSI Scanning Mobility Particle Sizer (SMPS™) spectrometer in a portable package that is about the size of a basketball. Easy to use, lightweight and battery-powered, the NanoScan SMPS™ spectrometer enables investigators to collect valuable nanoparticle size data. The NanoScan SMPS™ Nanoparticle Sizer spectrometer is suitable for a variety of applications, such as a multitude of mobile studies, workplace exposure monitoring, point source identification, and student lab education. Derived from TSI core technologies, the NanoScan SMPS spectrometer is an innovative, cost effective solution for real-time nanoparticle size measurements.

Technical Specifications: Weighing less than 20 pounds (including two hot-swappable batteries), the NanoScan SMPS™ Nanoparticle Sizer 3910 measures nanoparticle size distributions from 10 to 420 nm in one minute. Its internal Condensation Particle Counter (CPC) uses isopropyl alcohol as a working fluid, so the NanoScan is suitable for use in a variety of sensitive environments. Single particle mode allows the user to monitor particle concentrations of a single, user-set particle size. Data logging is built in to the instrument, so measurements may be made without the use of a laptop.

As a package, i.e. the model 3910 combined with the Optical Particle Sizer (OPS) 3330 enables users to measure three orders of size magnitude from 10 nm to 10 µm. These instruments are affordable, portable, and provide real-time data that can be merged with the multi-instrument manager (MIM) software. Used already for cabin measurements in cars and airplanes, the sky is literally the limit when it comes to new applications. Quantification thresholds reach to maximum concentrations of up to 150.000 particles per cm3.

Applications: General applied research; Indoor/outdoor air quality investigations; Nanotechnology/nanoparticle applications; Combustion/emission research; Mobile studies; Health effects/inhalation toxicology; Occupational hygiene/workplace exposure monitoring; Point source identification.

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New equipment adquired to improve NANBIOSIS U20

NANBIOSIS, U20. In Vivo Experimental Platform, led by Dr. Ibane Ibasolo, has been updated and improved as a result of its participation in the project FICTS1420-20, selected by the MICINN for co-financing by the FEDER Program in ICTS 2014-2020 (Equipment for setting standardized immunotoxicology assays for the U20 -NANBIOSIS I17 Action of the Investment Plan-)

A particle particle analyzer equipment (Exoid) has been inslalled at NANBIOSIS U20 for measurement of the concentration and the size of nanoparticles. The Exoid is the latest instrument from the Izon company to measure the physical characteristics of nanoparticles in electrolytic solution. Based on Tunable Resistive Pulse Sensing (TRPS) principles, the equipment is capable of measuring the size of the particles, their concentration and Z potential, through the use of a nanopore that allows measurements to be made in a defined size range.

Finally, a new upright laboratory freezer Liebherr _ SFNe 5227 has been adquired for the storage of the samples and reagents used in the different services of FVPR/U20,

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The role of microfluidics and 3D-bioprinting in the future of exosome therapy. A high impact review

Researchers of the NanoBioCel research group of the University of the Basque Country (UPV/EHU) and CIBER BBN, belonging to NANBIOSIS U10 Drug Formulation, Bioaraba, and CONICET Foundation of Argentina, have collaborated in a studio entitled: “The role of microfluidics and 3D-bioprinting in the future of the exosome therapy” which has been published in the journal Trends in Biotechnology, whose editorial seeks particularly relevant articles.

The importance of this publication lies in the novelty and potential of nanovesicles as new therapeutic agents and the versatility of microfluidic technology in combination with 3D bioprinting to bring nanovesicles closer to the clinic.

Article of reference:

Mikele Amondarain, Idoia Gallego, Gustavo Puras, Laura Saenz-del-Burgo, Carlos Luzzani, José Luis Pedraz, “The role of microfluidics and 3D-bioprinting in the future of exosome therapy”, Trends in Biotechnology,
2023, ISSN 0167-7799
https://doi.org/10.1016/j.tibtech.2023.05.006.

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Symposium Tribute to Prof. Pepe Becerra “40 years of the Bioengineering and Tissue Regeneration Laboratory (LABRET)”

Symposium on the occasion of the retirement of Prof. José Becerra Ratia: “40 years of the Bioengineering and Tissue Regeneration Laboratory (LABRET): tribute to Pepe Becerra”

We are pleased to inform about the Symposium organized by the LABRET group (Bioengineering and Tissue Regeneration Laboratory), University of Malaga, on the occasion of the retirement of Professor José Becerra.

The event will be held, only in person, on July 7 in the morning at the Faculty of Sciences of the University of Malaga

Download the program.

Prof. José Becerra was the Director of the Andalusian Center for Nanomedicine and Biotechnology (BIONAND) since February 2014, before the merger of Bionand and IBIMA (Biomedical Research Institute of Malaga) as IBIMA-Plataforma BIONAND. In fact, Prof, José Becerra took an important role in the incorporation of BIONAND into the ICTS NANBIOSIS till then integrated by Cento de Investigación Biomédica en Red (CIBER) in the area of Bioengineering, Biomaterial, and Centro de Cirugía de Mínima Invasión Jesús Usón, (CCMIJU) and he was also the first Director of the Unit 28 of NANBIOSIS.

In NANBIOSIS we want to show our gratitude to Prof. Becerra, with  appreciation and admiration for his contribution to strengthening this ICTS.

Related News:

Scientists of Bionand, University of Malaga and CIBER identify a new drug that could mitigate the consequences of COVID infection.
Stem cells and COVID-19 research.
CIBER-BBN and NANBIOSIS at CIBEREDH Scientific Annual Meeting
Bionand, recently incorporated to NANBIOSIS ICTS, among the three national biotechnology reference centers.
The Medicine of the Future needs the Nanomedicine Revolution. This is why
NANBIOSIS at the Assembly of Materplat
BIONAND incorporated to the Spanish ICTS Map as a new node of NANBIOSIS
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2023 Annual Conference of CIBER-BBN and NANBIOSIS

CIBER-BBN´s Annual Conference has been scheduled for November 6-8, 2023

This year, in the framework of a CIBER program to stimulate collaborations between clinical and technological groups, the conference will be organized in cooperation with a CIBER clinical area, CIBER-EHD: Hepatic and Digestive diseases. (An internal call of collaborative projects BBN-EHD will be open by). The scheme of the event will be slightly different from previous editions:

  • On Monday 6 the scientific sessions will be common for EHD and BBN, with appealing contents for the mixed audience.
  • On Tuesday 7 EHD and BBN sessions will be specific for each area in separate rooms (with common coffee break).
  • The anual session dedicated to NANBIOSIS is scheduled for the afternoon of the Tuesday 7th,
  • After this session we will cellebrate the annual meeting of the NANBIOSIS coordination Committee and the Scientific and Technical Advisory Board of NANBIOSIS.

We will come back with further details. Book the dates!

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Representatives of the Ministry of Science and Innovation visited unit 16 of NANBIOSIS

On May 16 representatives of the General Subdirectorate of Large Scientific-Technical Facilities of the Ministry of Science and Innovation visited unit 16 of NANBIOSIS (created by Centro de Investigación Biomédica en Red -CIBER-, and the University of Extermadura).

Mrs. Beatriz Albella Rodríguez and Mrs. María Jesús Marcos Crespo, got to know first-hand the facilities of unit 16 of the CTS NANBIOSIS of “Surface Characterization and Calorimetry“.

The visit was guided by the Scientific Director of Unit 16 of NANBIOSIS, Maria Luisa González Martín, and by Mr. Javier de Francisco Morcillo, Director of the Secretariat for Scientific Infrastructure and Technological Development Vice President for Research and Transfer of the University of Extremadura

The reason for the visit was to receive information on the use of European Regional Development Funds that have served to improve the infrastructures of the Spanish Map of Singular Scientific-Technical Infrastructures (ICTS, in Spanish) to support scientific research.

During the last years, this unit 16 of NANBIOSIS ICTS has enlarged its capacities through the project FICTS1420-14-09, an investment of 1.3 million euros, co-financed with FEDER funds, the Ministry of Science and Innovation, and Junta de Extremadura, Regional Ministry of Economy, Science and Digital Agency.

This Unit 16, located in Badajoz, offers the performance of tasks of physical-chemical characterization of surfaces using techniques such as ellipsometry, calorimetry, X-ray photoelectronic spectroscopy (XPS), and detection of secondary ions by means of mass spectrometry by time of flight (Tof-SIMS).

Related News

NANBIOSIS U16 enlarges its capacities with a new FlexPS-ARPES-E kit
New equipment for calorimetry and surface characterization for NANBIOSIS U16
Agreement signed with Spanish Goverment for the allocation of FEDER funds for NANBIOSIS ICTS
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U6-E16. Freeze Dryer

Freeze drying (also known as lyophilization) is a water (or other solvents) removal process typically used to preserve materials, to extend their shelf life or reduce its weight. Freeze drying works by freezing the material, then reducing the pressure and adding heat to allow the frozen water in the material to change directly to a vapor (sublimation).

Freeze drying occurs in three phases:

             1-Freezing

Freezing can be done in a freezer, a chilled bath (shell freezer) or on a shelf in the freeze dryer. Cooling the material below its triple point ensures that sublimation, rather than melting, will occur. This preserves its physical form.

              2-Primary Drying

Freeze drying’s second phase is primary drying (sublimation), in which the pressure is lowered and heat is added to the material in order for the water to sublimate. About 95% of the water in the material is removed in this phase. Primary drying can be a slow process.

             3-Secondary Drying

Freeze drying’s final phase is secondary drying (adsorption), during which the ionically-bound water molecules are removed. Most materials can be dried to 1-5% residual moisture.

Technical Specifications:

  • Vacuum pump: 7 m3/h
  • Condenser min. Temperature: – 80º C

Aplications:

Solvent removal is typically used to preserve materials, to extend their shelf life or reduce its weight.

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U6-E05. Tangential flow filtration system

Tangential flow filtration (TFF)  is a process of separation widely used in bio-pharmaceutical and food industries. It is different from other filtration systems in that the fluid is passed parallel to the filter, rather than being pushed through a membrane perpendicularly which can clog the filter media. This method is preferred for its continuous filtration and reproducible performance. The particles that pass through the membrane, the permeate, are put off to the side, while the rest, the retentate, is recycled back to the feed.

 Technical Specifications:

  • Volume: 10 ml
  • Filtration volume rate: 0.01 to 2300 ml/min

Aplications: Tangential flow filtration is used in the following processes:

Concentration: Increases the concentration of a solution by removing fluids while keeping the solute molecules. This process is done by selecting a filter significantly smaller than the solute molecules to allow for a higher retention of solute molecules.

 Diafiltration:  The separation of small and large particles, leaving the smaller particles behind without altering the overall concentration.

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