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U25-S08. NMR consultancy for processing and interpreting data (Onsite&Remote)

NMR consultancy for processing and interpreting data (Onsite&Remote)

Possibility of requesting expert advice and guidance while processing and interpreting MR data, especially at the preclinical and clinical levels.

Customer benefits

Customers not willing to install and proceed with a learning curve for using specific software can get expert advice and guidance on metabolite significance, interpretation and meaning.

Target customer

Researchers or companies dealing with MR datasets.

References

El-Abtah ME, Wenke MR, Talati P, Fu M, Kim D, Weerasekera A, He J, Vaynrub A, Vangel M, Rapalino O, Andronesi O, Arrillaga-Romany I, Forst DA, Yen YF, Rosen B, Batchelor TT, Gonzalez RG, Dietrich J, Gerstner ER, Ratai EM. Myo-Inositol Levels Measured with MR Spectroscopy Can Help Predict Failure of Antiangiogenic Treatment in Recurrent Glioblastoma. Radiology. 2022 Feb;302(2):410-418. doi: 10.1148/radiol.2021210826. Epub 2021 Nov 9. PMID: 34751617; PMCID: PMC8805659.

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U25-S09. Access to specific software and database (Remote) OUTSTANDING

Access to specific software and database (Remote) OUTSTANDING

Possibility of access to specific software developed in-house (postprocessing of MR spectroscopy data, conversion of spectroscopic data to canonical format, software for automated classification of MR spectroscopic data, decision support systems), provided disclaimer and agreement are signed. Databases with patient MR imaging and spectroscopic data, as well as epidemiological data from two multicentric european projects.

Customer benefits

Curated databases with a high quality level data for further studies. Software no currently available in public repositories. Interaction with researchers specialized in MR data.

Target customer

Customers willing to apply automated classification to their MR spectroscopic data, or willing to apply their methods to different clinically sound datasets.

References

  • Ungan G, et al. Using Single-Voxel Magnetic Resonance Spectroscopy Data Acquired at 1.5T to Classify Multivoxel Data at 3T: A Proof-of-Concept Study. Cancers (Basel). 2023 Jul 21;15(14):3709. doi: 10.3390/cancers15143709. PMID: 37509372; PMCID: PMC10377805.
  • Hernández-Villegas Y, et al. Extraction of artefactual MRS patterns from a large database using non-negative matrix factorization. NMR Biomed. 2022 Apr;35(4):e4193. doi: 10.1002/nbm.4193. Epub 2019 Dec 2. PMID: 31793715.
  • Hellström J, et al. Evaluation of the INTERPRET decision-support system: can it improve the diagnostic value of magnetic resonance spectroscopy of the brain? Neuroradiology. 2019 Jan;61(1):43-53. doi: 10.1007/s00234-018-2129-7. Epub 2018 Nov 15. PMID: 30443796; PMCID: PMC6336758.
  • Julià-Sapé M, et al. Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomes. NMR Biomed. 2016 Mar;29(3):371. doi: 10.1002/nbm.3483. Epub 2015 Dec 22. Erratum for: NMR Biomed. 2015 Dec;28(12):1772-87. Tate, Rosemary A [Corrected to Tate, A Rosemary]. PMID: 26915795.
  • Mocioiu V, et al. From raw data to data-analysis for magnetic resonance spectroscopy–the missing link: jMRUI2XML. BMC Bioinformatics. 2015 Nov 9;16:378. doi: 10.1186/s12859-015-0796-5. PMID: 26552737; PMCID: PMC4640235.
  • Ortega-Martorell S, et al. SpectraClassifier 1.0: a user friendly, automated MRS-based classifier-development system. BMC Bioinformatics. 2010 Feb 24;11:106. doi: 10.1186/1471-2105-11-106. PMID: 20181285; PMCID: PMC2846905.
  • Pérez-Ruiz A, et al. The INTERPRET Decision-Support System version 3.0 for evaluation of Magnetic Resonance Spectroscopy data from human brain tumours and other abnormal brain masses. BMC Bioinformatics. 2010 Nov 29;11:581. doi: 10.1186/1471-2105-11-581. PMID: 21114820; PMCID: PMC3004884.
  • Luts J, et al. A combined MRI and MRSI based multiclass system for brain tumour recognition using LS-SVMs with class probabilities and feature selection. Artif Intell Med. 2007 Jun;40(2):87-102. doi: 10.1016/j.artmed.2007.02.002. Epub 2007 Apr 26. PMID: 17466495.
  • Julià-Sapé M, et al. A multi-centre, web-accessible and quality control-checked database of in vivo MR spectra of brain tumour patients. MAGMA. 2006 Feb;19(1):22-33. doi: 10.1007/s10334-005-0023-x. Epub 2006 Feb 14. PMID: 16477436.

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U25-E01. Two AVANCE 250 MH z

Two AVANCE 250 MH z (5.8 T) spectrometers, one of them with an autosampler.

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U25-E02. An AVANCE 360 MH z

An AVANCE 360 MH z (8.4 T) spectrometer for the highresolution
analysis of samples in liquid state. Suitable for the structural determination of chemical molecules.

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U25-E03. AVII 400 MH z

AVII 400 MH z (9.4 T) spectrometer – with a narrow bore, equipped with a solid state accessory for working under Cross Polarization Magic-Angle-Spinning (CPMAS) conditions with materials under solid conditions. It has rotors with a variable capacity between 12-40 μl, 4 mm-diameter and a spinning rate up to 15000 Hz.

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U25-E04. AVIII 400 MH z

AVIII 400 MH z (9.4 T) spectrometer – with a narrow bore, equipped with a High Resolution Magic Angle Spinning (HRMAS) probe for analyzing semi-solid/semiliquid samples such as biopsies, cell extracts or biofluids. It has rotors with a variable capacity between 12-40 μl, 4 mm-diameter and a spinning rate up to 15000 Hz.

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U25-E05. AVANCE 500 MH z

AVANCE 500 MH z (11.7T) spectrometer with a 5 mm TCI cryoprobe with a high sensitivity increase (4X). It is connected to a high pressure liquid chromatography (HPLC), mass spectrometry (MS) and Diode Array (DAD) detectors. It has the possibility of using solid-phase extraction (SPE). It is unique for metabolomic studies and analysis of samples with limited mass and for the characterization of complex samples with compounds at a low concentration (μg), for biomedical and pharmacological applications, and analysis of natural products

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U25-E06. AVIII 600 MH z

AVIII 600 MH z (14T) spectrometer for high-resolution spectroscopy studies. It is equipped with a Triple Broad Band Inverse (TBI) detection-type probe which makes it suitable for proteomic and metabolomic studies, allowing the analysis of complex mixtures of very different origins (urine, plasma, serum, extracts, biopsies, etc).

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U25-E07. BioSpec 70/30 300 MH z

BioSpec 70/30 300 MH z (7T) spectrometer, suitable for in vivo applications, both spectroscopy and magnetic resonance imaging and microimaging applications. It is sui table for working with small animals, especially rats and mice, although in vitro analyses can also be carried out.

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U25-E08. Focused Microwave Fixation System

Focused Microwave Fixation System, to carry out the immediate sacrifice of small animals (rats, mice), preventing changes occurring in the metabolic pattern of the tissue due to post-mortem metabolism.

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