Toxicity evaluation on non-target organisms with the collaboration of NANBIOSIS U17 Confocal microscopy
Sara Jiménez-Jiménez, Georgiana Amariei, Karina Boltes, María Ángeles García and María Luisa Marina have recently published an article in the Journal of Chromatography A, ·mentioning the collaboration in the investigation of the ICTS “NANBIOSIS” U17 Confocal Microscopy Service of CIBER-BNN and the University of Alcalá.
The echocytotoxicity of racemic panthenol and dexpanthenol at different concentrations and exposure times in Spirodela polyrhiza has been studied using NANBIOSIS U17 Confocal Microscopy Service
“Panthenol (racemic mixture) and its isomer dexpanthenol have been classified as toxic for the aquatic environment by the European Regulation (EC 1272/2008). These studies are based on the natural emission (autofluorescence) of chlorophyll in different parts of the aquatic plant Spirodela polyrhiza (root, shoot and leaf). The estimation of the IC50 for each one of the compounds concludes different behavior of the compounds in the different parts of the plant, showing a higher toxicity for the racemic mixture panthenol”, explains Isabel Trabado, Technical Coordinator of NANBIOSIS U17
Article of reference:
Sara Jiménez-Jiménez, Georgiana Amariei, Karina Boltes, María Ángeles García and María Luisa Marina. Enantiomeric separation of panthenol by Capillary Electrophoresis. Analysis of commercial formulations and toxicity evaluation on non-target organisms. Journal of Chromatography A 1639 (2021) 461919. [DOI]
Financial support:
Spanish Ministry of Science and Innovation (research project PID2019-104913GB-I00). Dirección General de Universidades e Investigación de la Comunidad de Madrid (Spain), REMTAVARES (project S2018/EMT-4341). University of Alcalá for research projects CCG19/CC-068 and CCG19/IA-050, and for G.A.’s post-doctoral contract. Spanish Ministry of Science, Innovation and Universities for S.J.J.’s FPU pre-doctoral contract.
