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Nanbiosis

U9-S02. Synthesis of nanoparticles by wet methods and microfluidic technology

Synthesis of nanoparticles by wet methods and microfluidic technology

This facility is able to draw on a wide range of nanoparticles fabrication techniques by wet chemical approaches including the use of co-precipitation techniques, light-assisted co-deposition methods, hydrothermal, solvothermal synthesis. It also entails the use of alternative microfluidic reactors to achieve a higher control and reproducibility of targeted nanoparticles.

Customer benefits

The customers will benefit from the expertise of researchers to synthesize a wide variety of nanomaterials and nanocomposites including polymeric, magnetic, plasmonic, core-shell, nanorods, nanostars, nanoalloys of noble metal, transition metal and inorganic oxides. Microfluidic technology can be also designed to optimize specific demands of continuous production or in situ encapsulation of cargoes of interest.

Target customer

Companies, nanoparticle suppliers and research groups can benefit from custom-designed delivery of an ample portfolio of nanoparticle designs that can be applied in biomedicine, sensing, toxicology, delivery, decontamination and energy applications.

Additional information

Selected References:

  1. M.C. Ortega-Liebana, J.L. Hueso, R. Arenal, J. Santamaria, Titania-coated gold nanorods with expanded photocatalytic response. Enzyme-like glucose oxidation under near-infrared-illumination, Nanoscale, 9 (2017) 1787-1792.
  2. B. Rubio-Ruiz, A.M. Perez-Lopez, L. Uson, M.C. Ortega-Liebana, T. Valero, M. Arruebo, J.L. Hueso, V. Sebastian, J. Santamaria, A. Unciti-Broceta, In Cellulo Bioorthogonal Catalysis by Encapsulated AuPd Nanoalloys: Overcoming Intracellular Deactivation, Nano Letters, 23 (2023) 804-811.

Related Research Projects:

CADENCE – Catalytic Dual-Function Devices Against Cancer
09/2017 – 08/2022. Funding Entity: European Union H2020 – Advanced Grant. PI: Jesus Santamaria

https://www.nanbiosis.es/wp-content/uploads/2015/05/U9.-Synthesis-of-Nanoparticles-Samples.jpg

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U9-S01. Synthesis of nanoparticles by laser induced-pyrolysis

Synthesis of nanoparticles by laser induced-pyrolysis

The unit provides an automated system for the synthesis of nanoparticles using laser-induced pyrolysis of chemical precursors in gas and/or aerosol phase, which enables the generation of different type of nanoparticles. This service includes the possibility of selecting different feeding precursors either in gas, liquid or resuspended solids. The unit can also explore solid or liquid recollection of nanoparticles.

Customer benefits

This service can be quite convenient for generation of large quantities of magnetic or carbonaceous materials. It can be also ideal for custom-designed configurations of hybrid composites containing first and second transition metal oxides.

Target customer

This service is designed to supply nanoparticles for biomedical applications, including diagnosis and sensing. Research groups interested in generating large quantities for in vivo experiments, nanotoxicology or energy related applications are ideal customers.

Additional information

Selected References:

  1. A. Madrid, G. Martinez, F. Hornos, J. Bonet-Aleta, E. Calvo, A. Lozano, J.L. Hueso, Laser-induced tuning of carbon nanosensitizers to maximize nitrogen doping and reactive oxygen species production in the visible range, Catalysis Today, 422 (2023).
  2. G. Martinez, A. Malumbres, A. Lopez, R. Mallada, J.L. Hueso, J. Santamaria, Laser-Assisted Production of Carbon-Encapsulated Pt-Co Alloy Nanoparticles for Preferential Oxidation of Carbon Monoxide, Frontiers in Chemistry, 6 (2018).
  3. G. Martinez, A. Malumbres, R. Mallada, J.L. Hueso, S. Irusta, O. Bomati-Miguel, J. Santamaria, Use of a polyol liquid collection medium to obtain ultrasmall magnetic nanoparticles by laser pyrolysis, Nanotechnology, 23 (2012).

Selected Research Projects:

  1. Laser Pyrolysis For The Development Of Inorganic Nanoparticles –10/2017 – 09/2018. Funding Entity: TEIJIN LIMITED. PI: Jesús Santamaría
  2. PID2020-114926RB-I00: Generación asistida por láser de catalizadores de átomos aislados. Aplicaciones en energía, medio ambiente y salud. 09/2021 – 08/2024. Funding Entity: AGENCIA ESTATAL DE INVESTIGACIÓN PI: Jesús Santamaría

U09_JF_4522

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U3-E07. System for acidolactic cleavage (Boc/Bzl strategy), UNIQUE IN SPAIN

System for acidolactic cleavage of the peptide resin boundby anhydrous HF (Boc/Bzl strategy).

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U3-E06. Lyophilizers and SpeedVac evaporators

Lyophilizers and SpeedVac evaporators.

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U3-E05. Bohdan miniblocks

Bohdan miniblocks to generate libraries of medium- sized peptides.

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U3-E04. High-performance liquid chromatography (HPLC -MS) system with a diode array detector and coupled to a mass spectrometer

Analytical high-performance liquid chromatography (HPLC -MS ) system with a diode array detector and coupled to a mass spectrometer.

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U3-E03. High-performance liquid chromatography (HPLC) system with dual-wavelength UV detector

Analytical and prepartive high-performance liquid chromatography (HPLC ) system with dual-wavelength UV detector.

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U3-E02. High-performance liquid chromatography (HPLC) systems with a diode array detector.

Analytical and prepartive high-performance liquid chromatography (HPLC ) system with a diode array detector.

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U3-E01. Automatic synthesizer

Automatic synthesizer which can be operated at a range of scales (0.1-0.5 mmol) and with different types of chemistry (Fmoc and Boc) and coupling agents.

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U8-E01. Chemical vapor deposition (CVD) equipment for growth of CNTs and Graphene, Black Magic Pro 4-inch System ( AIXTRON Ltd)

The CVD machine grows both single and multiwalled carbon nanotubes, using both plasma-enhanced CVD (PECVD) and/or thermal CVD. It enables the production of advanced CNT Micro-Nano-Bio Systems (MNBS) for biological, chemical or biochemical analysis. As the suitability of the interface of any MNBS device is a critical point, the selective growth of CNT improves the electrode-electrolyte interface enhancing the biomonitoring.
Its specifications are:
›› Heat processing control up to 900ºC, with controlled ramps of up to 300ºC/min.
›› Plasma control; completely configurable source. Possibility of working without plasma.
›› Camera for 4” wafers.
›› Camera for following the process.
›› Possibility of processes in high vacuum (5 mBar) and at atmospheric pressure (800 mBar).
›› Process gases: hydrogen, methane, acetylene, argon,
ammonium and air.

See

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