BioSpec 70/30 300 MH z (7T) spectrometer, suitable for in vivo applications, both spectroscopy and magnetic resonance imaging and microimaging applications. It is sui table for working with small animals, especially rats and mice, although in vitro analyses can also be carried out.
Focused Microwave Fixation System, to carry out the immediate sacrifice of small animals (rats, mice), preventing changes occurring in the metabolic pattern of the tissue due to post-mortem metabolism.
Hypersense sample polarizer, to increase the sensitivity in in vitro and in vivo applications of the AV600 and BioSpec spectrometers. This method not only facilitates the detection of the hyperpolarized substrate in vivo, but also the rapid imaging of cellular metabolism
Advancements in medical technologies have enabled the development and regular use of minimally invasive procedures, which could also be termed image-guided surgery. A platform that can integrate the different imaging techniques is pivotal to aid their development.
NANBIOSIS Unit 24 has medical grade imaging (i.e. Cardiac Magnetic Resonance including delayed enhancement, high performance ultrasound systems, flat panel fluoroscopes, intravascular optical coherence tomography) integrated in a surgical environment, so that these technologies are available for comprehensive follow up of interventions or new surgical approaches. Generally, image acquisition is performed at baseline and serially during the predetermined duration of the study in order to assess the effectiveness of these surgeries on measurable endpoints to document improvement.
Customer benefits
The studies are tailored to the needs of each specific candidate intervention, can be implemented with different follow-up times and can be performed under regulatory requirements, since the performing institution is Certified for Good Laboratory Practices.
Thus the Service can be provided as proof-of-concept studies, full safety and efficacy or under GLPs to meet regulatory agencies’ guidelines and assure clinical translation, so that the customers can take their therapy to a clinical trial faster and more efficiently, thanks to the full range of capabilities offered in this service.
Target customer
The offered service can be of interest to scientists from academia willing to test a possible surgery and perform serial follow up of its outcomes, early-stage medical professionals requiring training in minimally invasive surgery, late-stage surgeons that need to test an idea for an improved surgical approach, commercial companies that need to test the implantation of a device and its effect under GLP studies to commercialize their product.
References
Intravascular ultrasound (IVUS) (ClearView Ultra. Boston Scientific)
Carbon dioxide injector for angiographies (CO2JECT Injector, ANGIODYNAMICS, Inc. NY, USA).
Computed Tomography (CT), Philips BRILLIANCE CT-6. The CT system includes 24 solid-state detectors that enable the acquisition of 6 simultaneous slices per 360º rotation, with a minimal slice thickness (0.6 mm) at an imaging time of 0.75 seconds per 360º for a full body scan.
These features make a high working speed possible with excellent image quality. The images can be processed in either basic or advanced mode from a workstation with the following software: Angio-CT, CINE mode, dynamic focal point reconstruction, multiplanar reconstruction (linear, curvilinear, etc), 3D multi tissue reconstruction (MIP, VR…), small volumes 3D analysis, and measurement tools for quantification (Q-CTA).
