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28 Oct

Mesoporous Nanoparticles: Properties, Synthesis and Biomedical Applications

Introduction Mesoporous nanoparticles are nanostructured materials containing pores with diameters[...]

27 Oct

NANBIOSIS launches an integrated service for recombinant antigen and antibody development

NANBIOSIS combines recombinant antigen design, custom antibody production and proteomics[...]

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Custom-Made Nanomaterials

Gold nanoparticles

From photothermal cancer therapy to advanced biosensing, gold nanostructures harness light-responsive properties for innovative biomedical applications.

Other metallic nanoparticles (Ag, Pt, Cu-Pt)

Silver and platinum nanoparticles bring together antimicrobial activity, advanced nanocatalysis and enhanced cancer radiotherapy.

Magnetic nanoparticles

Iron oxide-based nanoparticles enable magnetic hyperthermia, targeted drug delivery and enhanced MRI imaging.

Dendrimers

Versatile platforms for antiviral prevention, gene delivery, diagnostics and targeted therapies.

Polymeric nanoparticles

From targeted drug delivery to non-viral gene therapy, polymeric nanomaterials provide adaptable solutions for complex therapeutic challenges.

Lipid-like nanoparticles (liposomes, micelles, lipidic)

Delivery of drugs, proteins and genetic material, with applications ranging from cancer therapy to pulmonary and ocular treatments.

Protein-based nanoparticles

Fully recombinant protein nanostructures combine modular functionalization and targeted delivery for next-generation therapeutics, vaccines and regenerative medicine.

Mesoporous Nanoparticles

Exceptional cargo-loading capacity and controlled release for targeted therapy, bone regeneration and antibacterial applications.

Upconverting Nanoparticles

Convert near-infrared light into useful emissions, opening new possibilities for bioimaging, photodynamic therapy and light-controlled treatments.

Extracellular vesicles

Transport therapeutic proteins and nanoparticles, offering promising strategies for targeted cancer treatment and enzyme replacement.

Nanoemulsions

Versatile, low-energy nanoemulsion technologies enable the formulation of poorly water-soluble drugs and the development of functional polymeric nanocarriers.

Cerium oxide

Exploit reversible redox activity to combat oxidative stress, with promising applications in ophthalmology, cancer immunotherapy and diagnostic imaging.

Quantum dots

From fluorescent bioimaging to light-activated cancer therapy, quantum dots offer powerful optical properties for advanced biomedical applications.

Origamis

Programmable DNA nanostructures enable the precise positioning of therapeutic molecules, nanosensors and nanoparticles at the molecular scale.

Other Nanoparticles

From coatings for bone regeneration to programmable DNA architectures, these materials open new avenues in advanced biomaterials and nanotechnology.

Cutting-edge Biomedical Solutions

Overview
Customized biomolecules production & validation
Customized nanomedicines production & Preclinical Validation
Customized biomaterials production & Preclinical Validation
Diagnostics Devices Development & Validation
Quallity Control and Regulatory Affair

What are our “Cutting-Edge Biomedical Solutions” (CEBS)?

Integrated solutions to advanced challenges faced by biomedical researchers in nanomedicine, tissue engineering and regenerative medicine, diagnostic and medical devices, including the design and production of biomaterials and nanomaterials and their nanoconjugates, and the characterization of these bio-/nanomaterials, tissues and medicals devices from a physic-chemical, functional, toxicological and biological point of view up to preclinical validation. Complementing our list of “Cutting-Edge Biomedical Solutions” we offer a “Quallity Control and Regulatory Affair” Advisory Service Program developed within the framework of the projects “NANBIO-ACCESS”, RED2022-134685I/RED2024-154146-I founded by the Spanish Research State Agency

Customized biomolecules production & validation

Design & Production of biomolecules: Customized design and production services of biological molecules for tissue engineering, intelligent devices, implants, and specially therapeutic nanoconjugates and biosensor reagents. Applications such as therapeutic agents, targeting, surface functionalization (tissue engineering or scaffolds and biosensors), and IVD reagents. Validation: Purification, characterization, chemical modification and preservation of the developed biomolecules. Assays development and validation. Biomolecules functionalization and up-scaling. Main CEBS are:

Production of Anti-peptide Antibodies as a diagnostic tool.
Production of Protein-only nanomaterial platforms and their characterization for biomedicine.
Proteomics: recombinant protein production, purification and characterization.
NEW! Synthesis and monitoring of peptides for biomedical applications in animal models
NEW! Antibody- Biofunctionalized Nanoconjugates: Design, Production, and Characterization
NEW! Recombinant protein-based antibody production

Customized nanomedicines production & preclinical validation

Design & production of nanomedicines: Supply nanomaterials, nanoconjugates and nanoencapsulation of active ingredients for applications in nanomedicine: therapy, drug delivery, contrast agents (MRI, fluorescence) , theragnostic and reagents. Preclinical Validation: Preclinical characterisation of nanomedicines including physicochemical properties, in vitro and in vivo biological properties. immunology, toxicology and efficacy with appropriate animal models, at either regulatory (cGLP) or non-regulatory conditions. Biodistribution and metabolization follow up in animal models by NMR spectroscopy in tissues and biofluids. Main CEBS are:

Physicochemical characterization of nanomedicines
In vitro Characterization of Nanomedicines
In vivo Characterization of Nanomedicines
Preparation and evaluation of nanoparticles with antimicrobial properties.
Preparation and characterisation of enzyme-loaded nanovesicles.
Preparation of peptide-functionalized nanoparticles.
NEW! Development of aerosolized formulations for pulmonary administration.

Customized biomaterials production & Preclinical Validation

Design & Production of biomaterials: Design and production of scaffolds for tissue engineering using 3D printing technologies and others. Preclinical Validation: Preclinical validation of biomaterials, implants and surface coatings including surface and mechanical characterization and in vitro, biofilm and antibacterial properties studies of implants and in vivo biological properties with appropriate animal models, at either regulatory (cGLP) or non-regulatory conditions. Main CEBS are:

Analysis of biomedical devices and antimicrobial properties. Enhance the safety and efficacy of your biomedical device by evaluating its antimicrobial properties and behavior in realistic physiological environments.
NEW! Scaffolds by 3D bioprinting for tissue engineering and regeneration: Develop and validate customized 3D-bioprinted scaffolds with in vivo models, bridging advanced biomaterials research and real-world regenerative medicine applications.
Physicochemical, mechanical and surface characterization of biomaterials (under development): Mechanical, surface composition and surface characteristics by using the most sophisticated equipment and taking advantage of the expertise of scientist internationally recognized in the matter. This includes standard mechanical and surface composition studies.
In vitro and in vivo Characterization of Biomaterials (under development): NANBIOSIS offers a complete set of solutions up to the preclinical stage with a range of animal models. Our study plans are tailored to meet the demands of each biomaterial based medical product, developed in collaboration with the user, under either GLP and non-GLP conditions. All of this is possible thanks to our access to the most sophisticated equipment and taking advantage of the expertise of scientists internationally recognized in the matter.
In silico modelling (under development): NANBIOSIS supplies expertise in customized computational solutions for different tissues (cardiovascular system, human eye and others). Mainly expertise in the numerical-experimental models and experimental electrophysiology processing and modelling in cardiology and modelling of functional behaviour of tissues and organs is offered.

Diagnostics Devices Development & Validation

In vitro diagnostics & biomarkers & organ-on-a chip: Development and validation of prototypes, biosensing devices, organ-on-a chip devices for diagnostic. Production of bioreceptors against identified biomarkers. Discovery of biomarkers for diagnostic, follow-up and prognostic of diseases by NMR spectroscopy in biofluids and tissues. In vivo Bioimaging diagnostics & Validation: In vivo validation of contrast agents and development of nanoconjugates as contrast agents for MRI and fluorescence. Main CEBS are:

Affinity biomolecules production for diagnostics (under development): production and characterization of affinity receptors and reagents for in vitro diagnostic devices.
In vitro diagnostic Development & Validation (under development): Core Facilities in nanofabrication, biosensors development, microfluidics, bionano characterization and micro-nano technologies in Spain. NANBIOSIS supported the whole MNBS fabrication steps of the device and validation procedures of the developed IVD.
Biomarker’s discovery (under development): Discovery and quantification of biomarkers by NMR. Singular facilities for acquiring unique metabolic profiles of biofluids, cell lines and tissues by NMR techniques and others.
Organ-on-a-chip devices development & Validation (under development): Experts in microfluidics for the device’s development & validation. The customization of the technology needed, the design of the devices, the complete fabrication process, their encapsulation, micro electrodes incorporation and the characterization and test up to the technological support on the experimental uses. Several organ-on-a-chip devices have been developed based on organoids and IPScells, scaffolds and others).
Data-enabled techniques (under development): Experts related to the use of personalized virtual and augmented reality for pre-intraoperative planning, data-intensive methodologies, artificial intelligence techniques (machine learning) for virtual patients’ personalization (digital twins).
Nanoparticles as contrast agents for MRI and OCT (under development): NANBIOSIS approach offers novel synthetic strategies and experimental setup for the advanced preparation of a wide range of nanoparticles for MRI contrast agents.
Nanoconjugates for fluorescence (under development): NANBIOSIS approach offers novel synthetic strategies and experimental setup for the advanced preparation of a wide range of nanoparticles for fluorescence.

Mesoporous Nanoparticles: Properties, Synthesis and Biomedical Applications

NANBIOSIS launches an integrated service for recombinant antigen and antibody development